Evidence mapPaperPMID 41295387Full record

ArticleMarine drugs2025

Creating an Improved Diatoxanthin Production Line by Knocking Out

Charlotte Volpe, Zdenka Bartosova, Ralph Kissen, Per Winge, Marianne Nymark

Abstract read
In one paragraph

Article in Marine drugs, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Charlotte VolpeDepartment of Fisheries and New Biomarine Industry, SINTEF Ocean, Trondheim 7010, Norway.ORCID 0000-0002-3905-5645
Zdenka BartosovaDepartment of Biology, Norwegian University of Science and Technology, Trondheim 7491, Norway.ORCID 0000-0001-5644-1903
Ralph KissenDepartment of Biology, Norwegian University of Science and Technology, Trondheim 7491, Norway.
Per WingeDepartment of Biology, Norwegian University of Science and Technology, Trondheim 7491, Norway.ORCID 0000-0003-4380-1951
Marianne NymarkDepartment of Fisheries and New Biomarine Industry, SINTEF Ocean, Trondheim 7010, Norway.ORCID 0000-0002-0672-0653

Funding

The Research Council of Norway 344103
6 · The paper itself

Abstract

Diatoxanthin is a photoprotective carotenoid found in a few groups of microalgae displaying in vitro anti-inflammatory and anti-cancer properties, making it a promising candidate for nutraceutical, pharmaceutical, and cosmetic applications. However, large-scale production is currently nonexistent because of two major challenges: Instability during microalgae harvesting, where diatoxanthin is rapidly converted back to its inactive precursor diadinoxanthin under non-stressful light conditions, and dependence on prolonged exposure to high-intensity light, which is costly and technically challenging during indoor high-cell-density cultivation. The first limitation was previously addressed by knocking out zeaxanthin epoxidase 3 (ZEP3) in the marine diatom

Indexed as

DiatomsOxidoreductasesXanthophyllsLightMicroalgaeMutationdiadinoxanthindiatoxanthinOxidoreductasesXanthophyllszeaxanthin epoxidaseCRISPR/Cas9 gene editingdiatomsdiatoxanthinhigh-value productsPhaeodactylum tricornutum

Identifiers

PMID41295387
PMCPMC12654249

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.