ArticleAging clinical and experimental research2025
Evaluating the role of CHG index in predicting stroke risk among adults with varying glucose regulation.
Article in Aging clinical and experimental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed.
- Baseline versus cumulative cholesterol, high-density lipoprotein, and glucose index and stroke risk in individuals with cardiovascular-kidney-metabolic syndrome stages 0-3: evidence from the CHARLS study.Cardiovascular diabetology. Endocrinology reports · 2026Article
- Predictive value of cholesterol, high-density lipoprotein, and glucose index-obesity-derived index for stroke: a cohort study.Lipids in health and disease · 2026Article
- Associations between cholesterol, high-density lipoprotein, and glucose index and hyperuricemia in patients with diabetes.BMC endocrine disorders · 2026Article
- Nonlinear associations between the cholesterol, high-density lipoprotein, and glucose index and type 2 diabetes risk in Chinese prediabetic adults: a cohort study.Scientific reports · 2026Article
- Associations of cumulative exposure and dynamic trajectories of cholesterol-HDL-glucose (CHG) index with cardiovascular disease in middle-aged and older Chinese adults: a longitudinal analysis.Cardiovascular diabetology · 2026Article
- Cumulative exposure and patterns of the cholesterol-HDL-C-glucose index and risk of new-onset cardiometabolic multimorbidity: 9-year longitudinal evidence from CHARLS.Frontiers in nutrition · 2026Article
- Cholesterol, high-density lipoprotein, and glucose index as a cardiometabolic marker associated with heart rate variability and 1-year cardiovascular rehospitalization in chronic coronary syndromes with comorbid anxiety: a retrospective cohort study.Frontiers in endocrinology · 2026Article
- Association of cholesterol, high-density lipoprotein, and glucose (CHG) index with chronic kidney disease in Chinese community adults: findings from the REACTION study.Frontiers in nutrition · 2026Article
- The cholesterol, high-density lipoprotein, and glucose index as a metabolic-nutritional biomarker for risk stratification in hospitalized heart failure patients.Frontiers in nutrition · 2026Article
- Cholesterol, high-density lipoprotein, and glucose (CHG) index and incident impaired fasting glucose in Chinese adults: a retrospective longitudinal cohort study.Frontiers in nutrition · 2026Article
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6 authors.
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Abstract
backgroundStroke is a significant public health issue, with its risk influenced by various metabolic factors. The Cholesterol, High-Density Lipoprotein, Glucose (CHG) index has been identified as a valid stroke predictor. However, the impact of glucose-metabolic states on the relationship between CHG index and stroke risk remains unclear.
aimsThis study aimed to investigate how baseline, cumulative, and longitudinal changes in CHG index are associated with incident stroke risk across different glucose-metabolic states: normal glucose regulation (NGR), pre-diabetes (Pre-DM), and diabetes (DM).
methodsWe analyzed data from 8,728 adults aged 45 and older, collected through five waves of the China Health and Retirement Longitudinal Study (CHARLS) between 2011 and 2020. We assessed baseline, cumulative, and changes in the CHG index, with incident stroke as the primary outcome. Cox proportional hazards models quantified associations, and restricted cubic splines explored dose-response patterns.
resultsOver follow-up, 9.51% of participants had a stroke. The stroke incidence increased with higher CHG quartiles, except in individuals with DM. The highest CHG quartile (Q4) showed a 1.7-fold increased stroke risk (adjusted HR = 2.21 for NGR, adjusted HR = 2.02 for Pre-DM). No significant association was found in individuals with DM. Cumulative and longitudinal CHG index changes were positively associated with stroke risk, particularly in Pre-DM.
conclusionsElevated CHG index is linked to higher stroke risk, especially in individuals with NGR and Pre-DM, highlighting the importance of early monitoring and intervention for metabolic dysregulation-related stroke risk.
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