ArticleDiscover oncology2025
Evaluating the carcinogenic potential and molecular mechanisms of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the human stomach using organoids and bulk sequencing data: a multi-machine learning approach combined with computational simulation.
Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
Funding
Abstract
objectiveThis study investigates the impact of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the pathogenesis of gastric cancer and its associated molecular mechanisms, particularly the interaction between TCDD and key targets and pathways.
methodsWe employed various machine learning techniques and online databases to perform differential expression analysis on bulk gastric cancer sequencing data and organoid sequencing data to identify target genes and pathways related to TCDD and gastric cancer. A risk prediction model based on the expression levels of key intersection target genes was constructed. Network toxicology and molecular docking techniques were used to study the binding of TCDD to target proteins.
resultsA total of 24 genes were identified as potential target genes related to TCDD-induced gastric cancer. Machine learning analysis identified 5 core target genes as key intersection target genes of TCDD-induced gastric cancer, with the chemical carcinogenesis-receptor activation pathway, p53 signaling pathway, and IL-17 signaling pathway being the key pathways. Molecular docking revealed specific binding effects and binding sites between TCDD and intersection target proteins.
conclusionThis study suggests that TCDD may affect the pathogenesis of gastric cancer by targeting specific genes and pathways. Molecular docking simulations indicate that there is a significant binding specificity effect between TCDD and target proteins, which is key to gastric cancer development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.