Evidence map›Paper›PMID 41296443›Full record

ArticleCurrent issues in molecular biology2025

Regulation of TGF-β and BMP Signaling by Natural Triterpene Compounds in Pulmonary Arterial Hypertension (PAH).

Sila Ozlem Sener, Sabita Shaha, Saltan Gülçin İşcan, Ufuk Ozgen, Merve Yuzbasioglu Baran, Aleyna Nalcaoğlu, Md Talat Nasim

Abstract read
In one paragraph

Article in Current issues in molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sila Ozlem SenerDepartment of Pharmacognosy, Gulhane Faculty of Pharmacy, University of Health Sciences, Ankara 06018, Türkiye.ORCID 0000-0001-7679-7165
Sabita ShahaTranslational Medicine Laboratory, School of Pharmacy, Optometry and Medical Sciences, University of Bradford, Bradford BD7 1DP, UK.
Saltan Gülçin İşcanDepartment of Pharmacognosy, Faculty of Pharmacy, Ankara University, Ankara 06100, Türkiye.
Ufuk OzgenDepartment of Pharmacognosy, Faculty of Pharmacy, Karadeniz Technical University, Trabzon 61080, Türkiye.
Merve Yuzbasioglu BaranDepartment of Pharmacognosy, Gulhane Faculty of Pharmacy, University of Health Sciences, Ankara 06018, Türkiye.ORCID 0000-0002-7482-0429
Aleyna NalcaoğluDepartment of Molecular Biology and Genetics, Faculty of Science, Karadeniz Technical University, Trabzon 61080, Türkiye.ORCID 0000-0003-2528-8744
Md Talat NasimTranslational Medicine Laboratory, School of Pharmacy, Optometry and Medical Sciences, University of Bradford, Bradford BD7 1DP, UK.ORCID 0000-0003-1968-5663

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pulmonary arterial hypertension (PAH) is a devastating cardiovascular disorder caused by right heart failure leading to premature death. The TGFBR2 and BMPR-II receptors, which are members of the TGF-β receptor family, are considered promising targets for developing novel drugs in PAH. Lupeol and ψ-taraxasterol, naturally occurring triterpene molecules with proven anti-inflammatory, anti-cancer, and cardioprotective activities, hold considerable potential in the treatment of PAH. Hence, the present study aimed to evaluate the impacts of lupeol and ψ-taraxasterol isolated from

Indexed as

BMPR-IIlupeolPAHTGFBR2ψ-taraxasterol

Identifiers

PMID41296443
PMCPMC12650971

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.