Evidence map›Paper›PMID 41296858›Full record

ArticleScience advances2025

Widespread association of Polycomb complex-deposited histone H2A monoubiquitylation with enhancers and neuronal gene regulation.

Kailynn MacGillivray, Daniel Fusca, Luomeng Tan, Reta Aram, Arneet L Saltzman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kailynn MacGillivrayDepartment of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada.ORCID 0009-0009-2068-0481
Daniel FuscaDepartment of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada.ORCID 0009-0007-1679-2398
Luomeng TanDepartment of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada.
Reta AramDepartment of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada.
Arneet L SaltzmanDepartment of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada.ORCID 0000-0002-5827-3322

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
NIH HHS P40 OD010440
6 · The paper itself

Abstract

Disruption of histone H2A monoubiquitylation (H2AK119ub) causes neurodevelopmental disorders through poorly understood mechanisms. Polycomb complex-deposited H2AK119ub and trimethylation of histone H3 at lysine 27 (H3K27me3) can cooperatively maintain gene repression. However, the extent to which H2AK119ub functions independently of H3K27me3 to repress or potentiate gene expression, and the evolutionary conservation of these roles, remains unclear. Here, we address the interplay among Polycomb-deposited marks and chromatin states in

Indexed as

Enhancer Elements, GeneticGene Expression Regulation, DevelopmentalHistonesNeuronsPolycomb-Group ProteinsUbiquitinationAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsChromatinPromoter Regions, GeneticCaenorhabditis elegans ProteinsChromatinHistonesPolycomb-Group Proteins

Identifiers

PMID41296858
PMCPMC12652333

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.