ArticleScience (New York, N.Y.)2025
Local genetic adaptation to habitat in wild chimpanzees.
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Article in Science (New York, N.Y.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9citing papers in PubMed
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Who cites it
9 citing papers in PubMed.
- Evidence for multiple past introgressions among chimpanzee subspecies during warming periods.Communications biology · 2026Article
- Integrated environmental and genomic analysis reveals the drivers and genetic mechanisms of agro-climatic adaptation in geese.BMC genomics · 2026Article
- Behavioral shifts of reintroduced Milu deer Elaphurus davidianus in East Dongting lake of China.Scientific reports · 2025Article
- Accelerated evolution increased craniofacial divergence between humans and great apes.Proceedings. Biological sciences · 2025Article
- Effect of Substrate Compliance on the Jumping Mechanism of the Tree Frog (Biomimetics (Basel, Switzerland) · 2025Article
- Addressing missing context in regulatory variation across primate evolution.Current opinion in genetics & development · 2025Review
- Avoidance of reproductive conflict and the evolution of menopause in chimpanzees.Royal Society open science · 2025Article
- Article
- Genome-scale evolution in local populations of wild chimpanzees.Scientific reports · 2025Article
Corrections and comments
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Authors and funding
84 authors.
Harrison J OstridgeUCL Genetics Institute, Department of Genetics, Evolution and Environment, University College London, London, UK.ORCID 0000-0001-9113-6525
Claudia FontsereCenter for Evolutionary Hologenomics, The Globe Institute, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0003-2233-6026
Esther LizanoInstitute of Evolutionary Biology (UPF-CSIC), PRBB, Dr. Aiguader 88, Barcelona, Spain.ORCID 0000-0003-3304-9807
Daniela C SotoDepartment of Biochemistry & Molecular Medicine, Genome Center, MIND Institute, University of California, Davis, Davis, CA, USA.ORCID 0000-0002-6292-655X
Joshua M SchmidtFlinders Health and Medical Research Institute (FHMRI), Department of Ophthalmology, Flinders University Sturt Rd, Bedford Park, South Australia, Australia.ORCID 0000-0002-5862-7389
Vrishti SaxenaUCL Genetics Institute, Department of Genetics, Evolution and Environment, University College London, London, UK.ORCID 0009-0007-2329-723X
Marina Alvarez-EstapeInstitute of Evolutionary Biology (UPF-CSIC), PRBB, Dr. Aiguader 88, Barcelona, Spain.ORCID 0000-0001-8242-1092
Christopher D BarrattNaturalis Biodiversity Center, Darwinweg 2, Leiden, the Netherlands.
Paolo GrattonUniversity of Rome "Tor Vergata," Department of Biology, Via Cracovia, 1, Roma, Italia.ORCID 0000-0001-8464-4062
Gaëlle BocksbergerSenckenberg Biodiversity and Climate Research Centre (SBiK-F), Senckenberganlage 25, Frankfurt am Main, Germany.ORCID 0000-0002-3399-0405
Jack D LesterMax Planck Institute for Evolutionary Anthropology (MPI EVAN), Deutscher Platz 6, Leipzig, Germany.ORCID 0000-0002-0390-9792
Paula DieguezSenckenberg Museum for Natural History Görlitz, Senckenberg - Member of the Leibniz Association, Am Museum 1, Görlitz, Germany.ORCID 0000-0002-6951-2771
Anthony AgborMax Planck Institute for Evolutionary Anthropology (MPI EVAN), Deutscher Platz 6, Leipzig, Germany.
Samuel AngedakinMax Planck Institute for Evolutionary Anthropology (MPI EVAN), Deutscher Platz 6, Leipzig, Germany.ORCID 0000-0002-7471-3332
Alfred Kwabena AssumangDepartment of Wildlife and Range Management, Faculty of Renewable Natural Resources, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.ORCID 0009-0003-6972-3426
Emma BaileyMax Planck Institute for Evolutionary Anthropology (MPI EVAN), Deutscher Platz 6, Leipzig, Germany.
Donatienne BarubiyoMax Planck Institute for Evolutionary Anthropology (MPI EVAN), Deutscher Platz 6, Leipzig, Germany.
Mattia BessoneMax Planck Institute for Evolutionary Anthropology (MPI EVAN), Deutscher Platz 6, Leipzig, Germany.ORCID 0000-0002-8066-6413
Gregory BrazzolaMax Planck Institute for Evolutionary Anthropology (MPI EVAN), Deutscher Platz 6, Leipzig, Germany.
Rebecca ChancellorWest Chester University, Department of Psychology, West Chester, PA, USA.
Heather CohenGerman Centre for Integrative Biodiversity Research (iDiv) Halle-Leipzig-Jena, Puschstrasse 4, Leipzig, Germany.ORCID 0009-0002-3348-4366
Charlotte CouplandMax Planck Institute for Evolutionary Anthropology (MPI EVAN), Deutscher Platz 6, Leipzig, Germany.
Emmanuel DanquahDepartment of Wildlife and Range Management, Faculty of Renewable Natural Resources, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.ORCID 0000-0002-8305-5706
Tobias DeschnerMax Planck Institute for Evolutionary Anthropology (MPI EVAN), Deutscher Platz 6, Leipzig, Germany.ORCID 0000-0002-9873-316X
Laia DotrasJane Goodall Institute Spain in Senegal, Dindefelo Biological Station, Dindefelo, Kedougou, Senegal.ORCID 0000-0003-1308-4402
Jef DupainAntwerp Zoo Foundation, RZSA, Kon.Astridplein 26, Antwerp, Belgium.
Villard Ebot EgbeMax Planck Institute for Evolutionary Anthropology (MPI EVAN), Deutscher Platz 6, Leipzig, Germany.
Anne-Céline GranjonGerman Centre for Integrative Biodiversity Research (iDiv) Halle-Leipzig-Jena, Puschstrasse 4, Leipzig, Germany.ORCID 0000-0003-1426-523X
Josephine HeadArcus Foundation, 95 Regent Street, Cambridge, UK.ORCID 0000-0001-5816-7784
Daniela HedwigElephant Listening Project, K. Lisa Yang Center for Conservation Bioacoustics, Cornell Lab of Ornithology, Cornell University, 159 Sapsucker Woods Road, Ithaca, NY, USA.ORCID 0000-0002-7354-6165
Veerle HermansKMDA, Centre for Research and Conservation, Royal Zoological Society of Antwerp, Koningin Astridplein 20-26, Antwerp, Belgium.ORCID 0000-0002-5232-992X
R Adriana Hernandez-AguilarJane Goodall Institute Spain in Senegal, Dindefelo Biological Station, Dindefelo, Kedougou, Senegal.ORCID 0000-0002-9539-8669
Kathryn J JefferySchool of Natural Sciences, University of Stirling, UK.ORCID 0000-0002-2632-0008
Sorrel JonesMax Planck Institute for Evolutionary Anthropology (MPI EVAN), Deutscher Platz 6, Leipzig, Germany.ORCID 0000-0002-3579-7254
Jessica JunkerSenckenberg Museum for Natural History Görlitz, Senckenberg - Member of the Leibniz Association, Am Museum 1, Görlitz, Germany.ORCID 0000-0003-4775-6035
Parag KadamGreater Mahale Ecosystem Research and Conservation Project P.O. Box 120, Mpanda, Tanzania.ORCID 0000-0002-6534-4205
Michael KaiserMax Planck Institute for Evolutionary Anthropology (MPI EVAN), Deutscher Platz 6, Leipzig, Germany.ORCID 0000-0002-3098-1546
Ammie K KalanDepartment of Anthropology, University of Victoria, 3800 Finnerty Rd, Victoria, Canada.ORCID 0000-0003-1542-7077
Mbangi KambereMax Planck Institute for Evolutionary Anthropology (MPI EVAN), Deutscher Platz 6, Leipzig, Germany.
Ivonne KienastDepartment of Natural Resources and the Environment, Cornell University, Ithaca, NY, USA.ORCID 0009-0003-0243-1197
Deo KujirakwinjaWildlife Conservation Society (WCS), 2300 Southern Boulevard. Bronx, NY, USA.ORCID 0000-0003-2649-3854
Kevin E LangergraberSchool of Human Evolution and Social Change, Arizona State University, 900 Cady Mall, Tempe, AZ Arizona State University, PO Box 872402, Tempe, AZ, USA.ORCID 0000-0003-1697-4558
Juan LapuenteMax Planck Institute for Evolutionary Anthropology (MPI EVAN), Deutscher Platz 6, Leipzig, Germany.ORCID 0000-0002-6783-5585
Bradley LarsonFeralEarth Endeavors, Golden, CO, USA.ORCID 0000-0003-2848-6789
Anne LaudisoitEcoHealth Alliance, New York, NY, USA.ORCID 0000-0001-7626-9426
Kevin C LeeMax Planck Institute for Evolutionary Anthropology (MPI EVAN), Deutscher Platz 6, Leipzig, Germany.ORCID 0000-0002-5606-8683
Manuel LlanaJane Goodall Institute Spain in Senegal, Dindefelo Biological Station, Dindefelo, Kedougou, Senegal.ORCID 0000-0003-0570-2258
Giovanna MarettiMax Planck Institute for Evolutionary Anthropology (MPI EVAN), Deutscher Platz 6, Leipzig, Germany.ORCID 0009-0004-7506-3003
Rumen MartínMax Planck Institute for Evolutionary Anthropology (MPI EVAN), Deutscher Platz 6, Leipzig, Germany.
Amelia C MeierMax Planck Institute for Evolutionary Anthropology (MPI EVAN), Deutscher Platz 6, Leipzig, Germany.ORCID 0000-0002-2793-4634
David MorganLester E. Fisher Center for the Study and Conservation of Apes, Lincoln Park Zoo, 2001 North Clark Street, Chicago, IL, USA.ORCID 0000-0003-1266-2610
Emily NeilMax Planck Institute for Evolutionary Anthropology (MPI EVAN), Deutscher Platz 6, Leipzig, Germany.ORCID 0000-0001-8156-2344
Sonia NichollMax Planck Institute for Evolutionary Anthropology (MPI EVAN), Deutscher Platz 6, Leipzig, Germany.
Stuart NixonNorth of England Zoological Society, Chester Zoo, Upton by Chester, CH2 1LH, UK.ORCID 0000-0002-6867-287X
Emmanuelle NormandWild Chimpanzee Foundation (WCF), Abidjan, Côte d'Ivoire.
Christopher OrbellSchool of Natural Sciences, University of Stirling, UK.ORCID 0000-0001-9338-9411
Lucy Jayne OrmsbyMax Planck Institute for Evolutionary Anthropology (MPI EVAN), Deutscher Platz 6, Leipzig, Germany.ORCID 0009-0005-8959-4566
Robinson OrumeKorup Rainforest Conservation Society, c/o Korup National Park, P.O. Box 36 Mundemba, Southwest Region, Cameroon.ORCID 0000-0002-7055-6413
Liliana PachecoPrimate Project Inc., Miami, FL, USA.ORCID 0000-0001-7085-6064
Jodie PreeceMax Planck Institute for Evolutionary Anthropology (MPI EVAN), Deutscher Platz 6, Leipzig, Germany.
Sebastien RegnautWild Chimpanzee Foundation (WCF), Abidjan, Côte d'Ivoire.ORCID 0000-0002-2837-750X
Martha M RobbinsMax Planck Institute for Evolutionary Anthropology (MPI EVAN), Deutscher Platz 6, Leipzig, Germany.ORCID 0000-0002-6037-7542
Aaron RundusWest Chester University, Department of Psychology, West Chester, PA, USA.ORCID 0000-0002-8574-9138
Crickette SanzWashington University in Saint Louis, Department of Anthropology, One Brookings Drive, St. Louis, MO, USA.ORCID 0000-0003-2018-2721
Lilah SciakyMax Planck Institute for Evolutionary Anthropology (MPI EVAN), Deutscher Platz 6, Leipzig, Germany.ORCID 0000-0003-1815-6073
Volker SommerUniversity College London, Department of Anthropology, 14 Taviton Street, London, UK.ORCID 0000-0001-6749-3362
Fiona A StewartMax Planck Institute for Evolutionary Anthropology (MPI EVAN), Deutscher Platz 6, Leipzig, Germany.ORCID 0000-0002-4929-4711
Nikki TaggKMDA, Centre for Research and Conservation, Royal Zoological Society of Antwerp, Koningin Astridplein 20-26, Antwerp, Belgium.ORCID 0000-0002-1397-3720
Luc Roscelin TédonzongKMDA, Centre for Research and Conservation, Royal Zoological Society of Antwerp, Koningin Astridplein 20-26, Antwerp, Belgium.ORCID 0000-0002-9347-8630
Joost van SchijndelMax Planck Institute for Evolutionary Anthropology (MPI EVAN), Deutscher Platz 6, Leipzig, Germany.ORCID 0000-0002-2418-1884
Elleni VendrasFrankfurt Zoological Society, Bernhard-Grzimek-Allee 1, Frankfurt, Germany.ORCID 0000-0003-1891-1235
Erin G WesslingGerman Primate Center, Leibniz Institute for Primate Research, Göttingen, Germany.ORCID 0000-0001-9661-4354
Jacob WillieKMDA, Centre for Research and Conservation, Royal Zoological Society of Antwerp, Koningin Astridplein 20-26, Antwerp, Belgium.ORCID 0000-0002-8939-1321
Roman M WittigApe Social Mind Lab, Institute for Cognitive Sciences Marc Jeannerod, CNRS UMR 5229 CNRS, 67 bd Pinel, Bron CEDEX, France.ORCID 0000-0001-6490-4031
Yisa Ginath YuhMax Planck Institute for Evolutionary Anthropology (MPI EVAN), Deutscher Platz 6, Leipzig, Germany.
Kyle YurkiwMax Planck Institute for Evolutionary Anthropology (MPI EVAN), Deutscher Platz 6, Leipzig, Germany.
Linda VigilantMax Planck Institute for Evolutionary Anthropology (MPI EVAN), Deutscher Platz 6, Leipzig, Germany.ORCID 0000-0003-4509-1260
Alex K PielUniversity College London, Department of Anthropology, 14 Taviton Street, London, UK.ORCID 0000-0002-4674-537X
Christophe BoeschWild Chimpanzee Foundation (WCF), Abidjan, Côte d'Ivoire.ORCID 0000-0001-9538-7858
Hjalmar S KühlSenckenberg Museum for Natural History Görlitz, Senckenberg - Member of the Leibniz Association, Am Museum 1, Görlitz, Germany.
Megan Y DennisDepartment of Biochemistry & Molecular Medicine, Genome Center, MIND Institute, University of California, Davis, Davis, CA, USA.ORCID 0000-0002-8502-5420
Tomas Marques-BonetInstitute of Evolutionary Biology (UPF-CSIC), PRBB, Dr. Aiguader 88, Barcelona, Spain.ORCID 0000-0002-5597-3075
Mimi ArandjelovicGerman Centre for Integrative Biodiversity Research (iDiv) Halle-Leipzig-Jena, Puschstrasse 4, Leipzig, Germany.ORCID 0000-0001-8920-9684
Aida M AndrésUCL Genetics Institute, Department of Genetics, Evolution and Environment, University College London, London, UK.ORCID 0000-0002-8590-9672
Funding
The function of duplicated genes in human brain evolution and diseaseDP2MH119424 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI DENNIS, MEGAN Y · 2018 to 2018
$2.4MHuman gene duplications in neurodevelopment and diseaseR01MH132818 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI DENNIS, MEGAN Y · 2023 to 2024
$1.4MNatural Environment Research Council L002485NIMH NIH HHS DP2 MH119424NIMH NIH HHS R01 MH132818Wellcome Trust
Abstract
How populations adapt to their environment is a fundamental question in biology. Yet, we know surprisingly little about this process, especially for endangered species, such as nonhuman great apes. Chimpanzees, our closest living relatives, are particularly notable because they inhabit diverse habitats, from rainforest to woodland-savannah. Whether genetic adaptation facilitates such habitat diversity remains unknown, despite it having wide implications for evolutionary biology and conservation. By using newly sequenced exomes from 828 wild chimpanzees (388 postfiltering), we found evidence of fine-scale genetic adaptation to habitat, with signatures of positive selection in forest chimpanzees in the same genes underlying adaptation to malaria in humans. This work demonstrates the power of noninvasive samples to reveal genetic adaptations in endangered populations and highlights the importance of adaptive genetic diversity for chimpanzees.
Indexed as
Adaptation, PhysiologicalEcosystemPan troglodytesSelection, GeneticAnimalsEndangered SpeciesGenetic VariationGenomicsMalariaPopulation
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