Evidence map›Paper›PMID 41297693›Full record

ReviewJournal of molecular and cellular cardiology2026

Cyclic AMP-dependent regulation of ryanodine receptors in healthy and diseased hearts.

Mohit M Hulsurkar, Isabelle Ong, Joshua A Keefe, Issam H Abu-Taha, Dobromir Dobrev, Xander H T Wehrens

Abstract readReview
In one paragraph

Review in Journal of molecular and cellular cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Therapeutic effects of alprostadil on CClMolecular and cellular biochemistry · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mohit M HulsurkarCardiovascular Research Institute, Baylor College of Medicine, Houston, TX 77030, USA; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA.
Isabelle OngCardiovascular Research Institute, Baylor College of Medicine, Houston, TX 77030, USA; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA.
Joshua A KeefeCardiovascular Research Institute, Baylor College of Medicine, Houston, TX 77030, USA; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA.
Issam H Abu-TahaInstitute of Pharmacology, West German Heart and Vascular Center, University Duisburg-Essen, Essen, Germany.
Dobromir DobrevDepartment of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA; Institute of Pharmacology, West German Heart and Vascular Center, University Duisburg-Essen, Essen, Germany; Department of Medicine, Montreal Heart Institute and Université de Montréal, Montréal, Québec, Canada.
Xander H T WehrensCardiovascular Research Institute, Baylor College of Medicine, Houston, TX 77030, USA; Department of Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA; Institute of Pharmacology, West German Heart and Vascular Center, University Duisburg-Essen, Essen, Germany; Department of Medicine (Division of Cardiology), Baylor College of Medicine, Houston, TX 77030, USA; Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA; Department of Pediatrics (Division of Cardiology), Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: wehrens@bcm.edu.

Funding

The Role of Inflammasome in the Pathogenesis of Atrial FibrillationR01HL136389 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI Na Li · 2017 to 2026
$5.6M
Resolution of inflammation and atrial fibrillationR01HL165704 · NHLBI · UNIVERSITY OF MINNESOTA · PI SAMUEL C DUDLEY · 2023 to 2026
$2.9M
Cardiac fibroblast inflammasome and atrial myopathyR01HL163277 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI LI, NA · 2022 to 2025
$2.8M
Junctophilin-2 cleavage in ischemic heart diseaseR01HL153350 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI WEHRENS, XANDER H.T. · 2021 to 2024
$2.3M
Role of Nucleoside-Diphosphate Kinase Signaling in Atrial FibrillationR01HL160992 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI Xander H.T. Wehrens · 2023 to 2026
$2.1M
FKBP5 AND CARDIAC ARRHYTHMOGENESISR01HL164838 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI Na Li · 2024 to 2026
$1.7M
Role of inflammation in postoperative atrial fibrillationR01HL180477 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI Xander H.T. Wehrens · 2025 to 2026
$1.5M
Cardiomyocyte-fibroblast signaling in atrial fibrillationR01HL174510 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI Xander H.T. Wehrens · 2025 to 2026
$1.3M
Calcium Driven Fibroblast Dysregulation in Human Atrial Profibrotic RemodelingR01HL176651 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Eleonora Grandi · 2025 to 2026
$1.1M
Macrophage-mediated interleukin-6 signaling drives ryanodine receptor 2 calcium leak in postoperative atrial fibrillationF30HL172431 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI KEEFE, JOSHUA ANTHONY · 2024 to 2025
$99k
NHLBI NIH HHS F30 HL172431NHLBI NIH HHS R01 HL136389NHLBI NIH HHS R01 HL153350NHLBI NIH HHS R01 HL160992NHLBI NIH HHS R01 HL163277NHLBI NIH HHS R01 HL164838NHLBI NIH HHS R01 HL165704NHLBI NIH HHS R01 HL174510NHLBI NIH HHS R01 HL176651NHLBI NIH HHS R01 HL180477
6 · The paper itself

Abstract

Cyclic adenosine monophosphate (cAMP) is a critical second messenger in cardiomyocytes, regulating essential cellular functions. Upon G-protein-coupled receptor stimulation, adenylyl cyclase (AC) synthesizes cAMP, which phosphodiesterase (PDE) enzymes subsequently degrade. Recent studies challenge the traditional view of uniform cAMP signaling, revealing nanodomain-specific regulation within cardiomyocytes. This localized cAMP signaling modulates key Ca

Indexed as

Cyclic AMPHeart DiseasesMyocardiumRyanodine Receptor Calcium Release ChannelAnimalsCalciumCalcium SignalingHumansMyocytes, CardiacSarcoplasmic ReticulumSignal TransductionCalciumCyclic AMPRyanodine Receptor Calcium Release ChannelAtrial fibrillationCyclic adenosine monophosphateHeart failureNucleoside-diphosphate kinasesRyanodine receptor

Identifiers

PMID41297693
PMCPMC12968982

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.