Evidence map›Paper›PMID 41297948›Full record

ArticleInternal medicine (Tokyo, Japan)2026

Selpercatinib-induced Acalculous Cholecystitis in an Elderly Patient with RET Fusion-positive Non-small Cell Lung Cancer.

Takeru Ichikawa, Ken Sato, Yuto Sasano, Shoichiro Matsumoto, Suzuka Matsuoka, Yuki Takigawa, Hiromi Watanabe, Kenichiro Kudo, Akiko Sato, Keiichi Fujiwara and 1 more

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In one paragraph

Article in Internal medicine (Tokyo, Japan), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Takeru IchikawaDepartment of Respiratory Medicine, NHO Okayama Medical Center, Japan.
Ken SatoDepartment of Respiratory Medicine, NHO Okayama Medical Center, Japan.
Yuto SasanoDepartment of Respiratory Medicine, NHO Okayama Medical Center, Japan.
Shoichiro MatsumotoDepartment of Respiratory Medicine, NHO Okayama Medical Center, Japan.
Suzuka MatsuokaDepartment of Respiratory Medicine, NHO Okayama Medical Center, Japan.
Yuki TakigawaDepartment of Respiratory Medicine, NHO Okayama Medical Center, Japan.
Hiromi WatanabeDepartment of Respiratory Medicine, NHO Okayama Medical Center, Japan.
Kenichiro KudoDepartment of Respiratory Medicine, NHO Okayama Medical Center, Japan.
Akiko SatoDepartment of Respiratory Medicine, NHO Okayama Medical Center, Japan.
Keiichi FujiwaraDepartment of Respiratory Medicine, NHO Okayama Medical Center, Japan.
Takuo ShibayamaDepartment of Respiratory Medicine, NHO Okayama Medical Center, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The effectiveness of selpercatinib against RET-fusion-positive non-small cell lung cancer (NSCLC) in geriatric patients is underreported. We report the case of an 84-year-old woman in whom reduced-dose selpercatinib elicited a significant tumor response in KIF5B-RET fusion-positive NSCLC. However, she developed acalculous cholecystitis, which led to the discontinuation of the drug. This is the first reported case of selpercatinib-induced acalculous cholecystitis in a patient. The report highlighted the potential efficacy of selpercatinib in elderly patients while underscoring the risk of severe adverse events and emphasizing monitoring and personalized dose management.

Indexed as

Antineoplastic AgentsCarcinoma, Non-Small-Cell LungCholecystitisLung NeoplasmsProto-Oncogene Proteins c-retPyrazolesPyridinesAged, 80 and overFemaleHumansOncogene Proteins, FusionAntineoplastic AgentsOncogene Proteins, FusionProto-Oncogene Proteins c-retPyrazolesPyridinesRET protein, humanselpercatinibacalculous cholecystitisadverse drug reactionelderlynon-small cell lung cancerRET fusionselpercatinib

Identifiers

PMID41297948
PMCPMC13423777

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.