ReviewImmunity, inflammation and disease2025
The Role of Reactive Oxygen Species (ROS) in Periodontitis: A Potential Therapeutic Target.
Review in Immunity, inflammation and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Skipjack tuna bone-derived biocalcium ameliorates osteoblast and osteoclast differentiation through microRNA21 regulation.iScience · 2026Article
- Association between Albumin-to-Globulin Ratio and Periodontitis: A Cross-Sectional and Mendelian Randomisation Analysis.Oral health & preventive dentistry · 2026Article
- Macrophage Membrane-Coated Nanoparticles for Immunomodulation and Bone Regeneration: Emerging Applications in Oral and Dental Implant Therapy.Biomimetics (Basel, Switzerland) · 2026Review
- Cyclic Altitude Training, Mitochondrial Health, and the Oral-Airway Axis: Intermittent Hypoxia Between Adaptation and Disease.Journal of clinical medicine · 2026Review
- Association of oxidative stress-related gst gene polymorphisms with periodontitis susceptibility: A systematic review and meta-analysis.Journal of advanced periodontology & implant dentistry · 2026Article
- Nature meets immunity: curcumin's role in modulating neutrophil extracellular traps.Inflammopharmacology · 2026Review
- Silent Inflammation: A Critical Narrative Review of the Relationship Between Periodontal Disease and Psychosis-The Role of Oxidative Stress and Iatrogenic Comorbidities.Antioxidants (Basel, Switzerland) · 2026Review
- Alleviating effects of KGC19b on periodontal inflammation through anti-inflammatory and induction of osteogenic differentiation inJournal of ginseng research · 2026Article
- The Hypoxostat Model: A Conceptual Framework Linking Hypoxia, Oxidative Stress and Periodontal Breakdown Under Orthodontic Load.Antioxidants (Basel, Switzerland) · 2026Article
- Low salivary thioredoxin-1 levels in periodontitis.World journal of clinical cases · 2026Article
- Association Between Salivary Sirtuin-1 Levels and Periodontitis.Journal of clinical medicine · 2026Article
- Research Advances in Bionic Cell Membrane-Mediated Nanodrug Delivery Systems for the Treatment of Periodontitis with Osteoporosis.International journal of molecular sciences · 2026Review
- Periodontal severity and metabolic syndrome: A cross-sectional study from a tertiary care hospital in India.Bioinformation · 2026Article
- Oxidative stress and antioxidant pathways in the pathogenesis of periodontitis and peri-implantitis: mechanistic insights and therapeutic potentials.Frontiers in oral health · 2026Review
- Periodontitis and MASLD: a narrative review of the direct oral-hepatic pathway.Frontiers in cellular and infection microbiology · 2026Review
- Periodontal disease and endocrine imbalance: a molecular pathways perspective.Frontiers in dental medicine · 2026Review
- Association of GSTM1, GSTT1, and GSTP1 Gene Polymorphisms With Susceptibility to Periodontitis: A Systematic Review and Meta-Analysis With Exploratory Analysis of Apical Periodontitis.International journal of dentistry · 2026Review
- Remodeling of the mitochondrial quality control network: natural products intervening in diabetic retinopathy.Frontiers in pharmacology · 2026Review
- The Role of Reactive Oxygen Species (ROS) in Periodontitis: A Potential Therapeutic Target.Immunity, inflammation and disease · 2025Review
- A Comparative Evaluation of Serum and Salivary Antioxidant Levels in Healthy Controls, Gingivitis, and Periodontitis Patients.Journal of International Society of Preventive & Community DentistryArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
backgroundROS are pivotal in maintaining periodontal tissue health due to their dual role in physiological and pathological states. At physiological levels, ROS are essential for host defense, effectively eliminating pathogenic bacteria during inflammation and sustaining the homeostasis of the periodontal microenvironment. However, excessive ROS production disrupts the balance between oxidative activity and antioxidant defenses, leading to oxidative stress (OS). This imbalance exacerbates inflammation, damages cellular components, and drives periodontal tissue destruction. Recognizing the dual role of ROS underscores the importance of studying their regulatory mechanisms, which is crucial for advancing understanding and therapeutic strategies in periodontitis management.
objectiveThis review summarizes the latest research advancements on the molecular mechanisms linking ROS to the progression of periodontitis and explores related therapeutic strategies.
resultsThis review focuses on the pivotal role and specific mechanisms of periodontal tissue destruction by excess ROS, which mediate signaling pathways such as nuclear factor kappa B (NF-κB) and mitogen-activated protein kinase (MAPK), as well as the activation of OS response-associated proteins, including thioredoxin-interacting protein (TXNIP) and mitochondrial antiviral signaling protein (MAVS). Additionally, we provide a concise summary of emerging therapeutic strategies for periodontitis, including the use of antioxidants, photodynamic therapy (PDT), and nanomaterials. Gaining a more profound comprehension of these mechanisms may pave the way for the formulation of enhanced therapeutic strategies for periodontitis.
conclusionUnderstanding the interplay between ROS and periodontal tissue destruction is essential for advancing periodontitis research. Targeting the NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome with antioxidant and ROS-modulating therapies presents a promising strategy to mitigate both inflammation and OS, thereby reducing periodontal degradation.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.