ArticleNature communications2025
A 14-3-3 modulator of seed weight and quality for unlocking the yield potential of soybean.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Soybean Protein Quality and Quantity: Genetic Control and Environmental Influences.Plant, cell & environment · 2026Review
- 14-3-3 proteins: Central hubs in plant development and stress adaptation.Journal of integrative plant biology · 2026Review
- Identification of Genes Associated with Seed Weight and Development of Functional Markers forBiology · 2026Article
- Genome-Wide Identification and Characterization of thePlants (Basel, Switzerland) · 2026Article
- Natural variation of theFrontiers in plant science · 2026Article
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Authors and funding
10 authors.
Funding
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Abstract
Seed weight is a key component of crop yield. However, molecular mechanisms underlying soybean seed weight variation remain largely elusive. Here, we identify a major seed weight determining gene Glycine max SMALL SEED 6 (GmSMS6) that encodes a 14-3-3 protein. GmSMS6 physically and genetically interacts with the transcription factor GmbZIP151 and the RING-type E3 ligase GmUBQ1. GmSMS6 acts as a regulatory hub switch that coordinates the transcriptional activation activity and GmUBQ1-mediated stability of GmbZIP151, primarily repressing cellular expansion of soybean cotyledons. Knocking out GmSMS6 increases seed weight and protein content but decreases oil accumulation in multiple soybean genetic backgrounds. A loss-of-function allele of GmSMS6 is absent in available soybean resources, while the weakly expressed haplotype associated with heavy seed weight has undergone selection in G. max. These results provide insights into mechanisms underlying soybean domestication and highlight the importance of gene loss for improving crop yield and quality.
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