ArticleNPJ science of food2025
Metabolic signature of EAT-Lancet diet in relation to risk of frailty: a prospective cohort study.
Article in NPJ science of food, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- [Protein intake and preservation of function in old age : Current evidence and present research gaps].Zeitschrift fur Gerontologie und Geriatrie · 2026Review
- Dietary patterns and longitudinal frailty progression in older Chinese adults: a nationwide cohort study.The journal of nutrition, health & aging · 2026Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The EAT-Lancet Commission proposed a planetary health diet in 2019, yet its association with frailty remains unclear. This study aimed to examine the relationships between adherence to the EAT-Lancet diet, metabolomic profiles, and frailty risk among older adults. We included 44,465 participants from the UK Biobank, with a mean age of 55.88 years. Frailty was defined based on five physical criteria. Elastic net regression identified a 20-metabolite signature associated with the EAT-Lancet diet. Cox models showed that higher diet adherence was significantly associated with reduced frailty risk (HR: 0.51, 95% CI: 0.40 to 0.64). Each standard deviation increase in the metabolic signature was also associated with lower frailty risk (HR: 0.69, 95% CI: 0.63 to 0.75). Mediation analysis indicated that metabolites mediated 9.88% of the diet-frailty association. These findings suggest that greater adherence to the EAT-Lancet diet may lower frailty risk, partly mediated through specific metabolic pathways.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.