Evidence map›Paper›PMID 41298533›Full record

ArticleScientific reports2025

Decoding the anti-inflammatory properties of sesquiterpene coumarins from the active fractions of Ferula assa-foetida through integrated experimental and in silico analyses.

Mubarak A Alamri, Gamal A Soliman, Mohammed A Alamri, Rehab F Abdel-Rahman, Ahmed W Alhalabi, Raid S Almahmoud, Ibrahim M Alsagheir, Abdulrahman G Alharbi, Maged S Abdel-Kader

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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mubarak A AlamriDepartment of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, 11942, Al-Kharj, Saudi Arabia.
Gamal A SolimanDepartment of Pharmacology and Toxicology, College of Pharmacy, Prince Sattam Bin Abdulaziz University, 11942, Al-Kharj, Saudi Arabia. g.soliman@psau.edu.sa.
Mohammed A AlamriDepartment of Pharmacology and Toxicology, College of Pharmacy, Prince Sattam Bin Abdulaziz University, 11942, Al-Kharj, Saudi Arabia.
Rehab F Abdel-RahmanDepartment of Pharmacology, National Research Centre, Giza, 12622, Egypt.
Ahmed W AlhalabiCollege of Pharmacy, Prince Sattam Bin Abdulaziz University, 11942, Al-Kharj, Saudi Arabia.
Raid S AlmahmoudCollege of Pharmacy, Prince Sattam Bin Abdulaziz University, 11942, Al-Kharj, Saudi Arabia.
Ibrahim M AlsagheirCollege of Pharmacy, Prince Sattam Bin Abdulaziz University, 11942, Al-Kharj, Saudi Arabia.
Abdulrahman G AlharbiMaternity and Children's Hospital, Ministry of Health, 11942, Al-Kharj, Saudi Arabia.
Maged S Abdel-KaderDepartment of Pharmacognosy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, 11942, Al-Kharj, Saudi Arabia.

Funding

Deanship of Scientific Research, Prince Sattam bin Abdulaziz University PSAU/2024/03/31571
6 · The paper itself

Abstract

Ferula assa-foetida known as Asafoetida has a long-established history in folk medicine as a therapeutically useful drug in many disorders. The current paper explored the in vivo and in vitro anti-inflammatory activities of the plant. Liquid ethanol crude extract was subjected to liquid-to-liquid extraction, and the fractions so obtained were evaluated against the carrageenan-induced acute paw edema model in rats, to determine the anti-inflammatory effects. The fractions that gave the greatest activity-ethyl acetate and hexane- afforded four sesquiterpene coumarins: auraptene (1), umbelliprenin (2), galbanic acid (3), and kamolonol (4). The overall structure was determined through detailed spectroscopic investigation,

Indexed as

Anti-Inflammatory AgentsCoumarinsFerulaPlant ExtractsSesquiterpenesAnimalsEdemaLipopolysaccharidesMacrophagesMaleMiceMolecular Docking SimulationMolecular Dynamics SimulationNitric OxideRatsRAW 264.7 CellsAnti-Inflammatory AgentsCoumarinsLipopolysaccharidesNitric OxidePlant ExtractsSesquiterpenesAnti-inflammatoryAsafoetidaMolecular dockingMolecular dynamicNetwork pharmacologySesquiterpene coumarins

Identifiers

PMID41298533
PMCPMC12658108

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.