ArticleScientific reports2025
A lactylation-related gene signature predicts metastasis and prognosis in breast cancer.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Lactylation Remodels Tumorigenesis, Immune Microenvironment, and Therapeutic Response.Current issues in molecular biology · 2026Review
- Protein modification systems as cancer biomarkers and therapeutic targets.Precision clinical medicine · 2026Review
- Lactylation-mediated remodelling of the breast cancer microenvironment: single-cell multidimensional analysis and prognostic model construction.Frontiers in immunology · 2026Article
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Authors and funding
7 authors.
Funding
Abstract
Breast cancer (BC) remains one of the most prevalent and deadly cancers among women worldwide. Nearly one-third of early-stage cases eventually develop metastases, dropping the five-year survival rate to just 24%. Lactylation plays an important role in various tumor metastases, but its role in breast cancer is not yet fully understood. Here, we developed a prognostic model based on lactylation-related genes using data from The Cancer Genome Atlas (TCGA), validated by three Gene Expression Omnibus (GEO) datasets. Functional enrichment analysis identified key biological processes, and further analyses explored associations with clinical characteristics, immune cell infiltration, drug sensitivity, and molecular docking affinities. Finally, we further verified the functional role of lactylation and prognostic genes through experimental verification. Our study demonstrates that lactylation-related genes serve as predictive biomarkers for BC metastasis and proposed novel therapeutic targets for further clinical intervention.
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Registered trials
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