Evidence map›Paper›PMID 41298658›Full record

ArticleScientific reports2025

Elevated Lactobacillus salivarius and genus Akkermansia in fecal samples of Taiwanese patients with parkinson's disease and diabetes mellitus.

Sheng-Ta Tsai, Zi-Lun Lai, Ming-Kuei Lu, Marina Walther-Antonio, Yi-Yao Hsu, Dy-San Chao, Chia-Yang Chen, Sara Vettleson-Trutza, John S Kuo, Chia-Chun Yang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Antioxidants (Basel, Switzerland) · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Sheng-Ta TsaiDivision of Parkinson's Disease and Movement Disorders, Department of Neurology, China Medical University Hospital, Taichung, Taiwan.
Zi-Lun LaiDepartment of Laboratory Medicine, China Medical University Hospital, China Medical University, Taichung, Taiwan.
Ming-Kuei LuDivision of Parkinson's Disease and Movement Disorders, Department of Neurology, China Medical University Hospital, Taichung, Taiwan.
Marina Walther-AntonioDepartment of Surgery, Mayo Clinic, Rochester, MN, USA.
Yi-Yao HsuDepartment of Laboratory Medicine, China Medical University Hospital, China Medical University, Taichung, Taiwan.
Dy-San ChaoDepartment of Laboratory Medicine, China Medical University Hospital, China Medical University, Taichung, Taiwan.
Chia-Yang ChenGraduate Institute of Biomedical Sciences, College of Medicine, China Medical University, Taichung, Taiwan.
Sara Vettleson-TrutzaMayo Clinic Neural Engineering and Precision Surgery Laboratories, Rochester, MN, USA.
John S KuoNeuroscience and Brain Disease Center, China Medical University, Taichung, Taiwan.
Chia-Chun YangInstitute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.
Ching-Chu ChenSchool of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan.
Po-Ren HsuehSchool of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.
Der-Yang ChoGraduate Institute of Biomedical Sciences, College of Medicine, China Medical University, Taichung, Taiwan. d5057@mail.cmuh.org.tw.
Chon-Haw TsaiDivision of Parkinson's Disease and Movement Disorders, Department of Neurology, China Medical University Hospital, Taichung, Taiwan. windymovement@gmail.com.

Funding

China Medical University Hospital C1110812016China Medical University Hospital C1110812016-9China Medical University Hospital DMR 114-175Ministry of Education Yu Shan Scholar awardMinistry of Science and Technology, Taiwan NSTC 112-2314-B-039-004
6 · The paper itself

Abstract

Recent advancements in non-invasive collection methods and technological innovations have significantly enhanced the analysis of human gut microbiota, which has become a key approach for understanding complex disease pathogenesis. Epidemiological studies and clinical trials have revealed intriguing connections between Parkinson's disease (PD) and diabetes mellitus (DM). In this study, microbial populations from fecal samples of patients with PD and DM were analyzed. The prospective cohorts included four groups: PD only (n = 32), DM only (n = 170), and concurrent PD and DM (n = 10), matched with healthy controls (n = 98) by age and comorbidities. Fecal samples underwent full-length (V1-V9) 16 S rRNA sequencing analysis, and clinical and laboratory variables were collected. The results revealed an increased abundance of Lactobacillus salivarius in patients with PD (linear discriminant analysis [LDA] = 2.58, p value < 0.05) or DM (LDA = 2.20) compared to healthy controls. Similarly, an elevated abundance of the genus Akkermansia was observed in patients with PD (LDA = 4.39) or DM (LDA = 3.92). These findings suggest that gut microbiota alterations, particularly involving L. salivarius and Akkermansia spp., may play a role in the pathogenesis of PD and DM, warranting further investigation into their significance.

Indexed as

AkkermansiaDiabetes MellitusFecesLactobacillusParkinson DiseaseAgedCase-Control StudiesFemaleGastrointestinal MicrobiomeHumansMaleMiddle AgedProspective StudiesRNA, Ribosomal, 16STaiwanRNA, Ribosomal, 16S16S rRNA full-length sequencingAkkermansiaDiabetes mellitusGut microbiotaLactobacillus salivariusParkinson

Identifiers

PMID41298658
PMCPMC12657968

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.