Prevalence and association of fall-risk-increasing drugs (FRIDs) with fall-related head and non-head injuries in older adults: a retrospective database study.

Waranun Chimyaem, Yanee Choksomngam, Nida Buawangpong, Nalinee Yingchankul, Kanokporn Pinyopornpanish

Abstract readObservational Study

In one paragraph

Observational study in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Adequate Psychodrugs Do Not Impair Gait Speed in Older, Relatively Healthy, Independent Patients: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2026
Article

4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Waranun ChimyaemDepartment of Family Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Yanee ChoksomngamDepartment of Family Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. yanee.choksomngam@cmu.ac.th.

Nida BuawangpongDepartment of Family Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Nalinee YingchankulDepartment of Family Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Kanokporn PinyopornpanishDepartment of Family Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Falls are a leading cause of morbidity and mortality in older adults, with head injuries posing significant risk. Fall-risk-increasing drugs (FRIDs) contribute to falls, but their relationship with head injuries remains unclear. This observational, cross-sectional study aimed to examine the prevalence of fall-risk-increasing drug (FRID) use and the association between specific FRID classes and fall-related head injuries in older adults. We analyzed medical records of 1,085 adults aged ≥ 60 years who presented with falls at a tertiary hospital in Northern Thailand between January and December 2023. Of these, 47.1% sustained head injuries and 71.7% used FRIDs. The most frequently used FRIDs were opioids (33.0%), anticholinergics (26.8%), and antihistamines (22.5%). Multivariable logistic regression revealed that Z-drugs (aOR = 3.09, 95% CI: 1.15-8.26, p = 0.025), antipsychotics (aOR = 2.75, 95% CI: 1.40-5.39, p = 0.003), and benzodiazepines (aOR = 1.76, 95% CI: 1.16-2.66, p = 0.008) were positively associated with head injuries. Conversely, anticholinergics (aOR = 0.54, 95% CI: 0.40-0.72, p < 0.001) and opioids (aOR = 0.39, 95% CI: 0.30-0.51, p < 0.001) showed negative associations. These findings emphasize the need for careful medication management to prevent serious fall-related outcomes in geriatric populations.

Indexed as

Accidental FallsCraniocerebral TraumaAgedAged, 80 and overAnalgesics, OpioidAntipsychotic AgentsBenzodiazepinesCholinergic AntagonistsCross-Sectional StudiesDatabases, FactualFemaleHistamine AntagonistsHumansMaleMiddle AgedPrevalenceAnalgesics, OpioidAntipsychotic AgentsBenzodiazepinesCholinergic AntagonistsHistamine AntagonistsFall-risk-increasing drugsFallsFRIDsHead injuriesOlder adults

Identifiers

PMID41298794

DOI10.1038/s41598-025-30331-8

PMCPMC12749420

What Socratic holds

Textmetadata

LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.