Evidence map›Paper›PMID 41298957›Full record

ReviewCommunications biology2025

Mitotic dynamics of the nuclear lamina in the backstage of chromosome separation.

Julien Picotto, Pascale Bertrand, Gaëlle Pennarun

Abstract readReview
In one paragraph

Review in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Julien PicottoUniversité Paris Cité, Inserm, CEA, Stabilité Génétique Cellules Souches et Radiations, LREV/iRCM/IBFJ, Fontenay-aux-Roses, France.
Pascale BertrandUniversité Paris Cité, Inserm, CEA, Stabilité Génétique Cellules Souches et Radiations, LREV/iRCM/IBFJ, Fontenay-aux-Roses, France. pascale.bertrand@cea.fr.ORCID http://orcid.org/0000-0002-9019-742X
Gaëlle PennarunUniversité Paris Cité, Inserm, CEA, Stabilité Génétique Cellules Souches et Radiations, LREV/iRCM/IBFJ, Fontenay-aux-Roses, France. gaelle.pennarun@cea.fr.ORCID http://orcid.org/0000-0001-9881-9345

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The regulation of mitosis is essential for genome inheritance and stability. In mammals, many cellular ultrastructures, including the nuclear envelope, undergo significant morphological changes to facilitate chromosome separation. In particular, the lamina, a key nuclear envelope subcompartment, experiences drastic structural changes throughout mitosis, from its rapid and complete dissociation during the nuclear envelope breakdown to its reassembly during mitotic exit. Interestingly, intermediate states of assembly of both A and B-type lamins, the major components of the lamina, have been reported to support mitotic progression and spindle formation. Here we review the various contributions of lamins to mitosis, beyond nuclear envelope breakdown and reassembly. In addition, we discuss how lamin defects in pathological contexts affect mitosis and thus genome stability.

Indexed as

Chromosome SegregationMitosisNuclear LaminaAnimalsHumansLaminsNuclear EnvelopeLamins

Identifiers

PMID41298957
PMCPMC12657873

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.