ReviewMolecular psychiatry2026
Impact of distinct neurotransmitter release modes on neuronal signaling.
Review in Molecular psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- The Selectivity Implications of Docking Libraries with Greater and Lesser Similarities to Bio-like Molecules.Journal of medicinal chemistry · 2026Article
- Synaptotagmin isoforms differentially regulate glutamate and GABA release in the lateral habenula.bioRxiv : the preprint server for biology · 2026Article
- The Axon as a Self-Modifying Computational System: Autonomous Inference, Adaptive Propagation, and AI-Enabled Mechanistic Insight.International journal of molecular sciences · 2026Review
- A modern reinterpretation of the "kidney governs bone" theory: systemic regulation of the neuro-endocrine-immune network via the brain-bone axis and traditional chinese medicine intervention strategies.Frontiers in pharmacology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Neuronal communication is governed by a diverse repertoire of neurotransmitter release modes, each with distinct molecular machinery and functional roles. Beyond rapid, high-fidelity synchronous release, asynchronous release supports sustained neurotransmitter output, while spontaneous, action-potential-independent release plays a critical role in synaptic development, homeostasis, and plasticity. Complementing these forms of release, slow neurotransmission mediated by monoamines and neuropeptides acts over longer timescales to shape network-wide activity. This review explores the unique mechanisms of each mode, highlighting compelling evidence that spontaneous and evoked release are functionally segregated through separate vesicle pools and distinct postsynaptic receptors. We also examine the molecular complexity and debated physiological roles of asynchronous release, particularly at excitatory synapses, and the specialized machinery of neuromodulatory systems. A comprehensive understanding of these varied release mechanisms is fundamental to neuroscience and opens novel therapeutic avenues. Targeting the unique molecular components of each release mode offers a promising strategy for developing more precise treatments for neurological and psychiatric disorders.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.