ReviewOncogene2026
NLRPs and tumor: research progress from molecular mechanisms to clinical applications.
Review in Oncogene, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Article
- Advances in understanding the dual roles of testicular immune responses: From immune privilege to inflammation.Seminars in immunopathology · 2026Review
- Stratified assessment of platelets in sepsis: from dynamic counts to functional phenotypes.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The NOD-like receptor protein (NLRP) family, a vital part of the NOD-like receptor (NLR) superfamily, plays a key role in regulating apoptosis, triggering inflammatory responses, and mediating innate immunity. Recently, NLRPs have become important in maintaining immune balance because they detect disturbances inside and outside cells, guiding the formation of functional inflammasomes or serving as negative regulators in immune signaling pathways. Inflammasome assembly is a core process through which NLRPs carry out their biological functions, mainly by activating caspase-1. This activation leads to the maturation and release of pro-inflammatory cytokines, such as interleukin-1β (IL-1β) and interleukin-18 (IL-18), which are essential for controlling anti-tumor immunity. This review thoroughly examines the diverse roles of NLRPs in various cancer types, outlines the complex regulatory networks that control their activity, and discusses the potential clinical implications of these molecular mechanisms, providing insights for therapeutic development.
Indexed as
Identifiers
41299065What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.