Evidence map›Paper›PMID 41299080›Full record

ArticleThe EMBO journal2026

Dual interference with host neuropeptide signaling allows parasitoid wasp to hijack host sugar metabolism.

Zhi-Zhi Wang, Ruo-Fei Ma, Li-Cheng Gu, Li-Zhi Wang, Ting Chen, Pei Yang, Jia-Ni Zou, Jiang-Yan Zhu, Zhi-Wei Wu, Yue-Nan Zhou and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The EMBO journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Zhi-Zhi Wang *Institute of Insect Sciences, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, China.ORCID http://orcid.org/0000-0003-0189-1741
Ruo-Fei Ma *Institute of Insect Sciences, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, China.
Li-Cheng GuInstitute of Insect Sciences, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, China.
Li-Zhi WangInstitute of Insect Sciences, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, China.
Ting ChenInstitute of Insect Sciences, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, China.
Pei YangInstitute of Insect Sciences, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, China.
Jia-Ni ZouInstitute of Insect Sciences, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, China.
Jiang-Yan ZhuInstitute of Insect Sciences, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, China.
Zhi-Wei WuInstitute of Insect Sciences, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, China.
Yue-Nan ZhouInstitute of Insect Sciences, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, China.ORCID http://orcid.org/0000-0002-1445-5087
Min ShiMinistry of Agriculture and Rural Affairs Key Lab of Molecular Biology of Crop Pathogens and Insect Pests, Zhejiang University, Hangzhou, China.
Xing-Xing ShenInstitute of Insect Sciences, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, China.
Jian-Hua HuangInstitute of Insect Sciences, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, China.ORCID http://orcid.org/0000-0001-6509-1765
Xue-Xin ChenInstitute of Insect Sciences, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, China. xxchen@zju.edu.cn.ORCID http://orcid.org/0000-0002-9109-8853

Funding

MOE | Fundamental Research Funds for the Central Universities (Fundamental Research Fund for the Central Universities) 226-2024-00070MOST | National Key Research and Development Program of China (NKPs) 2023YFD1400800MOST | National Natural Science Foundation of China (NSFC) 32272607MOST | NSFC | National Natural Science Foundation of China-Zhejiang Joint Fund for the Integration of Industrialization and Informatization (NSFC-Zhejiang Joint Fund) U22A20485
6 · The paper itself

Abstract

Changes in host carbohydrate metabolism determine the outcome of host-parasite relationships, but the underlying mechanistic basis remains elusive. Here, we show that the parasitoid wasp Cotesia vestalis induces trehalose accumulation in its host, the moth Plutella xylostella, largely independently of insulin/adipokinetic hormone signalling and food intake. Instead, parasitoids rewire host carbohydrate metabolism via two pathways activated by the evolutionarily conserved short neuropeptide F (sNPF), a functional analogue of mammalian neuropeptide Y. Parasitoid-derived teratocytes secrete sNPF that interacts with the sNPF receptor (sNPFR) on host cells, and contributes to host hypertrehalosemia by promoting glycogenolysis in the fat body. We further find that a parasitoid-symbiotic virus induces expression of host-encoded sNPF, which stimulates glycolysis in the host midgut. Furthermore, we show that the host sNPF-sNPFR complex stimulates G

Indexed as

Carbohydrate MetabolismHost-Parasite InteractionsMothsNeuropeptidesWaspsAnimalsInsect ProteinsMolecular Docking SimulationReceptors, NeuropeptideSignal TransductionInsect Proteinsneuropeptide FNeuropeptidesReceptors, NeuropeptideHost–parasite InteractionHumoral FactorShort Neuropeptide FSugar Metabolism

Identifiers

PMID41299080
PMCPMC12992715

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.