Evidence map›Paper›PMID 41299157›Full record

ReviewFunctional & integrative genomics2025

Non-coding RNAs-regulated SLC7A11 modulates ferroptosis: a new strategy for cancer therapy.

Xinyu Niu, Jiawen Nie, Lijie Zhang, Feng Chen, Zhijuan Lin

Abstract readReview
PubMed Publisher
In one paragraph

Review in Functional & integrative genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xinyu Niu *Key Laboratory of Immune Microenvironment and Inflammatory Disease Research in Universities of Shandong Province, School of Basic Medical Sciences, Shandong Second Medical University, Weifang, 261053, Shandong, P.R. China.
Jiawen Nie *Key Laboratory of Immune Microenvironment and Inflammatory Disease Research in Universities of Shandong Province, School of Basic Medical Sciences, Shandong Second Medical University, Weifang, 261053, Shandong, P.R. China.
Lijie Zhang *Key Laboratory of Immune Microenvironment and Inflammatory Disease Research in Universities of Shandong Province, School of Basic Medical Sciences, Shandong Second Medical University, Weifang, 261053, Shandong, P.R. China.
Feng ChenFirst Department of Gastrointestinal Surgery, Weifang Hospital of Traditional Chinese Medicine, Shandong Second Medical University, Weifang, 261041, Shandong, P.R. China. 15610279319@163.com.
Zhijuan LinKey Laboratory of Immune Microenvironment and Inflammatory Disease Research in Universities of Shandong Province, School of Basic Medical Sciences, Shandong Second Medical University, Weifang, 261053, Shandong, P.R. China. eva1949@163.com.

Funding

National Natural Science Foundation of China No.32000495Natural Science Foundation of Shandong Province No.ZR2020MH202Weifang Science and Technology Development Plan Project No. 2024YX039
6 · The paper itself

Abstract

Ferroptosis is an iron-dependent form of regulated cell death that plays a dual role in cancer progression and suppression. Solute carrier family 7 member 11 (SLC7A11/xCT) is a key regulator of tumor cell ferroptosis that promotes cystine uptake and glutathione synthesis. However, the regulatory mechanisms of ferroptosis remain unclear, which limits its application in cancer therapy. Recent studies have found that non-coding RNAs (ncRNAs), including lncRNAs, miRNAs, and circRNAs, participate in the process of ferroptosis by regulating SLC7A11. In this review, we summarize the mechanisms of ncRNAs that regulate SLC7A11 expression through transcriptional, post-transcriptional, and epigenetic ways to influence ferroptosis in tumor cells. Furthermore, we explore the potential use of the ncRNA/SLC7A11 axis as a therapeutic target for tumors, and introduce new strategies aimed at inducing ferroptosis and overcoming chemotherapy resistance, such as natural compounds targeting ncRNA and nano-delivery systems. This review will enhance our understanding of the potential of ncRNAs targeting SLC7A11 in tumor therapy and offer new approaches to investigating novel tumor diagnostic and therapeutic biochemical indicators in future clinical treatments.

Indexed as

Amino Acid Transport System y+FerroptosisNeoplasmsRNA, UntranslatedAnimalsGene Expression Regulation, NeoplasticHumansAmino Acid Transport System y+RNA, UntranslatedSLC7A11 protein, humanCancer therapyFerroptosisNon-coding RNASLC7A11

Identifiers

PMID41299157

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.