Evidence map›Paper›PMID 41299172›Full record

ArticleNature2026

Progressive coevolution of the yeast centromere and kinetochore.

Jana Helsen, Kausthubh Ramachandran, Gavin Sherlock, Gautam Dey

Abstract read
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Polarization as a Process: The Potential of Process Ontology for Understanding Cellular Symmetry Breaking.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026
    Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jana HelsenDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA. jana.helsen@embl.de.ORCID 0000-0002-2637-7047
Kausthubh RamachandranCell Biology and Biophysics, European Molecular Biology Laboratory, Heidelberg, Germany.ORCID 0000-0002-6221-8166
Gavin SherlockDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA. gsherloc@stanford.edu.ORCID 0000-0002-1692-4983
Gautam DeyCell Biology and Biophysics, European Molecular Biology Laboratory, Heidelberg, Germany. gautam.dey@embl.de.ORCID 0000-0003-1416-6223

Funding

Multisizer 4e - equipment for "Fitness Effects of Beneficial Mutations"R35GM131824 · NIGMS · STANFORD UNIVERSITY · PI Gavin J Sherlock · 2019 to 2026
$3.6M
NIGMS NIH HHS R35 GM131824
6 · The paper itself

Abstract

During mitosis, stable but dynamic interactions between centromere DNA and the kinetochore complex enable accurate and efficient chromosome segregation. Even though many proteins of the kinetochore are highly conserved

Indexed as

CentromereChromosomes, FungalEvolution, MolecularKinetochoresSaccharomyces cerevisiaeGenetic DriftPhylogenySelection, Genetic

Identifiers

PMID41299172
PMCPMC12925627

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.