Evidence map›Paper›PMID 41299344›Full record

Trial reportBMC surgery2025

The effects of Pressure-Controlled Volume-Guaranteed ventilation (PCV-VG) on Postoperative Pulmonary Complications (PPCs) of oral and maxillofacial patients undergoing free flap reconstruction: a randomized controlled trial.

Yun Liu, Ling Gao, Xiaoming Lyv, Xiang Zhang, Dan Zhou, Guoli Xiong, Ruili Liu, Xudong Yang

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yun Liu *Department of Anesthesiology, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology, Beijing, 100081, China.
Ling Gao *Department of Anesthesiology, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology, Beijing, 100081, China.
Xiaoming LyvDepartment of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology, Beijing, 100081, China.
Xiang ZhangDepartment of Anesthesiology, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology, Beijing, 100081, China.
Dan ZhouDepartment of Anesthesiology, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology, Beijing, 100081, China.
Guoli XiongDepartment of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology, Beijing, 100081, China.
Ruili LiuDepartment of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology, Beijing, 100081, China.
Xudong YangDepartment of Anesthesiology, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology, Beijing, 100081, China. kqyangxudong@163.com.

Funding

New Clinical Techniques and Therapies of Peking University School and Hospital of Stomatology PKUSSNCT-15A12Young Clinical Research Fund of the Chinese Stomatological Association CSA-A2021-02
6 · The paper itself

Abstract

backgroundTo analyze the effects of pressure-controlled volume-guaranteed ventilation (PCV-VG) and volume-controlled ventilation (VCV) on postoperative pulmonary complications (PPCs) after oral and maxillofacial surgery with free flap reconstruction.

methodsThis was a prospective, randomized, controlled trial comparing two intraoperative ventilation strategies. Two hundred and forty patients who underwent oral and maxillofacial surgery with free flap reconstruction were randomly allocated to either VCV group (n = 120) or the PCV-VG group (n = 120). After induction of anesthesia, for both modes of ventilation, the target tidal volume (VT) was 6 mL/kg and the respiratory rate was adjusted to avoid hypercarbia. The primary outcome was a composite of postoperative pulmonary complications within the first seven postoperative days. The peak and mean inspiratory pressures and dynamic compliance were recorded at T1(the time after the patients entered the operation room), T2 (the time of skin incision), T3 (the time when anastomosing blood vessels), T4 (the time of closure of the incision). And oxygenation index (OI) and arterial partial pressure of oxygen (PaO

resultsThe two groups had similar characteristics at baseline. 26.7% patients in PCV-VG group, and 34.2% patients in VCV group experienced PPCs within the first 7 days after surgery (P = 0.051). In the first 7 days after surgery, the PCV-VG group had a better postoperative survival probability, but without significant statistical differences (Log-rank test, P = 0.056). But in tracheotomy patients, PCV-VG group had a lower incidence of PPCs (P < 0.05). In addition, the PCV-VG group had a shorter length of stay in hospital after surgery (9 days vs. 10 days, P = 0.041). Furthermore, PCV-VG group had significantly lower peak inspiratory pressure and greater dynamic compliance than VCV group (P < 0.05). At the same time, OI and PaO

conclusionsFor patients undergoing oral and maxillofacial surgery with free flap reconstruction who were at intermediate or high risk of developing PPCs, PCV-VG could shorten the length of stay in hospital and showed a trend toward being superior to VCV in its ability to provide ventilation with lower peak inspiratory pressure, greater dynamic compliance, and better oxygenation. Meanwhile, in tracheotomy patients, the PCV-VG group had a lower incidence of PPCs.

trial registrationChinese Clinical Trial Registry, www.chictr.org.cn , number: ChiCTR2200060865; Registered on June 12, 2022.

Indexed as

Free Tissue FlapsLung DiseasesOral Surgical ProceduresPlastic Surgery ProceduresPostoperative ComplicationsRespiration, ArtificialAdultAgedFemaleHumansMaleMiddle AgedProspective StudiesTidal VolumeFree flap reconstructionOral and maxillofacial surgeryPostoperative pulmonary complications (PPCs)Pressure-controlled volume-guaranteed ventilation (PCV-VG)

Identifiers

PMID41299344
PMCPMC12659554

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.