Evidence map›Paper›PMID 41299541›Full record

ReviewGenome biology2025

Molecular effects of transposable element sequences in mammalian cells.

Ming-Ching C Wen, Joshua D Welch

Abstract readReview
In one paragraph

Review in Genome biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ming-Ching C WenGilbert S Omenn Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.
Joshua D WelchGilbert S Omenn Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA. welchjd@umich.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transposable elements (TEs) are often epigenetically repressed in eukaryotic cells, but still affect the molecular state of the cell in certain contexts. A flurry of recent studies have elucidated new effects of TE sequences in eukaryotic cells. We review these emerging molecular effects of TEs, including a variety of new mechanisms by which TE sequences affect the cell, including pre- and post-transcriptional regulation of gene expression; cell-to-cell transmission of genes within a multicellular organism through virus-like activity; and RNA-guided DNA insertion. Recent demonstration of TE-guided genome editing underscores the importance of these investigations for both basic and translational research. Future work is needed to continue to unravel the molecular effects of TE sequences across developmental stages, across cell types, and in various diseases.

Indexed as

DNA Transposable ElementsAnimalsEpigenesis, GeneticGene EditingGene Expression RegulationHumansMammalsDNA Transposable Elements

Identifiers

PMID41299541
PMCPMC12649098

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.