Evidence map›Paper›PMID 41299577›Full record

ArticleDiabetology & metabolic syndrome2025

Lp(a) levels and ischemic stroke recurrence in type 2 diabetes mellitus.

Aichun Cheng, Fangyuan Zhang, Aoming Jin, Jing Xue, Zhiyuan Feng, Xia Meng, Yongjun Wang, Jie Xu

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PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetology & metabolic syndrome, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Aichun Cheng *Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, No. 119 S Fourth Ring W Rd, Fengtai District, Beijing, 100070, China.
Fangyuan Zhang *Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, No. 119 S Fourth Ring W Rd, Fengtai District, Beijing, 100070, China.
Aoming JinDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, No. 119 S Fourth Ring W Rd, Fengtai District, Beijing, 100070, China.
Jing XueDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, No. 119 S Fourth Ring W Rd, Fengtai District, Beijing, 100070, China.
Zhiyuan FengDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, No. 119 S Fourth Ring W Rd, Fengtai District, Beijing, 100070, China.
Xia MengDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, No. 119 S Fourth Ring W Rd, Fengtai District, Beijing, 100070, China.
Yongjun WangDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, No. 119 S Fourth Ring W Rd, Fengtai District, Beijing, 100070, China. yongjunwang@ncrcnd.org.cn.
Jie XuDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, No. 119 S Fourth Ring W Rd, Fengtai District, Beijing, 100070, China. xujie@ncrcnd.org.cn.

Funding

National Key R&D Program of China 2022YFC2502400National Key R&D Program of China 2022YFC2502403National Natural Science Foundation of China 82371294
6 · The paper itself

Abstract

backgroundWe investigated the association between lipoprotein(a) [Lp(a)] levels and stroke recurrence in type 2 diabetes mellitus (T2DM) patients with recent acute ischemic stroke or transient ischemic attack (TIA).

methodsThis study included 3,311 T2DM patients with recent acute ischemic stroke or TIA and complete Lp(a) data from the Third China National Stroke Registry. The patients were categorized into three groups based on the 40th and 70th percentiles of the Lp(a): ≤13.1, 13.1 to 29.2 and ≥ 29.2 mg/dL. The primary outcome was stroke recurrence within one year, with incident cases further classified as either ischemic or hemorrhagic. Cox proportional hazards regression and restricted cubic splines were used to evaluate these associations.

resultsA total of 3311 patients (2142 men, 64.69%, median age 63) were analyzed. Restricted cubic spline analysis revealed a U-shaped relationship between Lp(a) levels and the risk of stroke recurrence. After adjusting for cardiovascular risk factors, patients with Lp(a) levels ≤ 13.1 mg/dL or ≥ 29.2 mg/dL had hazard ratios of 1.34 (95% confidence interval (CI), 1.02-1.76) and 1.35 (95% CI, 1.01-1.79), respectively, for total stroke compared to those with Lp(a) levels between 13.1 and 29.2 mg/dL. The corresponding hazard ratios were 1.36 (95% CI, 1.02-1.81) and 1.36 (95% CI, 1.01-1.83) for ischemic stroke and 0.88 (95% CI, 0.37-2.09) and 0.77 (95% CI, 0.31-1.94) for hemorrhagic stroke, respectively.

conclusionsBoth low and high levels of Lp(a) are associated with an increased risk of stroke recurrence in T2DM patients with a recent history of acute ischemic stroke or TIA, demonstrating a U-shaped relationship.

Indexed as

Lp(a)Stroke recurrenceType 2 diabetes mellitus

Identifiers

PMID41299577
PMCPMC12659546

What Socratic holds

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.