ArticleEuropean journal of medical research2025
Evaluating the relationship between 24-h urine output and clinical outcomes in critically injured trauma patients: a retrospective cohort study.
Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo investigate the relationship between urine output in the first 24 h after ICU admission and the 28-day, ICU, and hospital mortality rate in trauma patients.
methodsClinical data of trauma patients from the Medical Information Mart for Intensive Care IV database and the eICU Collaborative Research Database were extracted. The non-linear relationship between 24-h urine output and clinical outcomes was described using restricted cubic splines. Patients were divided into three groups (LUO, MUO, and HUO) based on their 24-h urine output, followed by pairwise propensity score matching to create three matched cohorts. To evaluate the association between urine output and clinical outcomes, we applied log-rank tests, multivariate logistic regression, inverse probability of treatment weighting (IPTW)-adjusted logistic regression, and a doubly robust estimation model.
resultsThis study included 8,501 trauma patients from MIMIC-IV and 3,309 from the eICU database. Compared with the LUO group, the MUO group had a lower risk of 28-day mortality (OR 0.77, 95% CI 0.64-0.94, p < 0.01), and this association remained robust across multiple analytical models. However, no significant differences in 28-day mortality between the HUO and MUO groups were observed except in the log-rank test, and no strong correlation between high urine output and clinical prognosis was found in other models.
conclusionIn ICU-admitted trauma patients, a 24-h urine output of less than 800 mL is an independent risk factor for 28-day and ICU mortality.
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