Evidence map›Paper›PMID 41299767›Full record

ArticleActa neuropathologica communications2025

CISD2 ensures adequate ER-mitochondrial coupling, critically supporting mitochondrial function in neurons.

Jens Loncke, Ian de Ridder, Rita La Rovere, Annika Vaarmann, Guizhen Fan, Karan Ahuja, Irina Serysheva, Catherine Verfaillie, Martijn Kerkhofs, Jan B Parys and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neuropathologica communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jens LonckeLaboratory for Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine, KU Leuven, Campus Gasthuisberg O/N-1 B-802, Herestraat 49, 3000, Leuven, Belgium.
Ian de RidderLaboratory for Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine, KU Leuven, Campus Gasthuisberg O/N-1 B-802, Herestraat 49, 3000, Leuven, Belgium.
Rita La RovereLaboratory for Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine, KU Leuven, Campus Gasthuisberg O/N-1 B-802, Herestraat 49, 3000, Leuven, Belgium.
Annika VaarmannDepartment of Pharmacology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.
Guizhen FanDepartment of Biochemistry and Molecular Biology, Structural Biology Imaging Center, McGovern Medical School at UTHealth at Houston, 6431 Fannin Street, Houston, TX, USA.
Karan AhujaDepartment of Development and Regeneration, Stem Cell Institute, KU Leuven, 3000 Leuven, Belgium, Leuven, Belgium.
Irina SeryshevaDepartment of Biochemistry and Molecular Biology, Structural Biology Imaging Center, McGovern Medical School at UTHealth at Houston, 6431 Fannin Street, Houston, TX, USA.
Catherine VerfaillieDepartment of Development and Regeneration, Stem Cell Institute, KU Leuven, 3000 Leuven, Belgium, Leuven, Belgium.
Martijn KerkhofsLaboratory for Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine, KU Leuven, Campus Gasthuisberg O/N-1 B-802, Herestraat 49, 3000, Leuven, Belgium.
Jan B ParysLaboratory for Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine, KU Leuven, Campus Gasthuisberg O/N-1 B-802, Herestraat 49, 3000, Leuven, Belgium.
Allen KaasikDepartment of Pharmacology, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.
Geert Bultynck *Laboratory for Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine, KU Leuven, Campus Gasthuisberg O/N-1 B-802, Herestraat 49, 3000, Leuven, Belgium. geert.bultynck@kuleuven.be.
Tim Vervliet *Laboratory for Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine, KU Leuven, Campus Gasthuisberg O/N-1 B-802, Herestraat 49, 3000, Leuven, Belgium. tim.vervliet@kuleuven.be.

Funding

Mechanisms of inositol trisphosphate receptor-mediated calcium signalingR35GM153178 · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · 2025 to 2025
$516k
American Heart Association-American Stroke Association 23CDA1048883American Heart Foundation 23CDA1048883Central European Leuven Strategic Alliance CELSA/23/031Estonian Research Competency Council PRG2145Fonds Wetenschappelijk Onderzoek 1131324NFonds Wetenschappelijk Onderzoek 12ZG121NFonds Wetenschappelijk Onderzoek S001221NFonds Wetenschappelijk Onderzoek W0.014.22NFoundation for the National Institutes of Health R35GM153178NIGMS NIH HHS R35 GM153178NINDS NIH HHS R21 NS138590Onderzoeksraad, KU Leuven C14/19/099
6 · The paper itself

Abstract

Loss of Cisd2, an iron-sulfur cluster transfer protein, results in type 2 Wolfram syndrome (WS2), a disorder associated with severe impacts on pancreatic β cell and neuronal functions. Cisd2 has been implicated in regulating intracellular Ca

Indexed as

Endoplasmic ReticulumMitochondriaNeuronsAnimalsAutophagyCalciumCalcium SignalingHeLa CellsHumansMembrane ProteinsMiceCalciumCISD2 protein, humanMembrane ProteinsApoptosisCa2+ signalingCisd2ER-mitochondria contact sitesNeurodegenerationWolfram syndrome

Identifiers

PMID41299767
PMCPMC12659354

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.