ArticleBrain sciences2025
Transcranial Random Noise Stimulation over the Dorsolateral Prefrontal Cortex in Patients with Parkinson's Disease and Mild Cognitive Impairment: A Pilot Study.
Article in Brain sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- The Use of Non-Invasive Brain Stimulation Techniques in Subjects with Parkinson's Disease and Mild Cognitive Impairment: A Systematic Review.Brain sciences · 2026Review
- Editorial: Advancing the Frontiers of Non-Invasive Neuromodulation in Research and Clinical Practice.Brain sciences · 2026Article
- Neuromodulation of Working Memory: Mechanisms, Targets, and Behavioral Outcomes.Neuroscience insights · 2026Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesMild cognitive impairment (MCI) is common in Parkinson's disease (PD) and often precedes dementia. Non-invasive brain stimulation (NIBS) techniques such as transcranial random noise stimulation (tRNS) targeting dorsolateral prefrontal cortex (DLPFC) may offer additional benefits for cognitive and motor functions in PD-MCI patients.
methodsUsing a randomized, double-blind, cross-over study, participants with PD-MCI completed two stimulation sessions (real vs. sham) 7 days apart. Cognitive and motor outcomes (MoCA, FAB, FAS, MDS-UPDRS motor) were assessed pre- and post-stimulation; stimulation was administered "online" during executive training. Scores before and after the sessions have been compared, as well as their variations between the two groups.
resultsTen subjects were in the study. Patients undergoing real tRNS showed improvements in global cognition and executive functioning compared to those undergoing sham stimulation, as demonstrated by significant increase in MoCA and FAB scores. In contrast, the motor examination showed no significant differences.
conclusionsThis preliminary study showed that a single session of DLPFC-tRNS stimulation produced domain-specific cognitive benefits in PD-MCI patients. Studies with multiple stimulation sessions and larger samples are needed to confirm the effect of this non-pharmacological therapeutic option in PD-MCI.
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