ReviewBrain sciences2025
Vagus Nerve Stimulation Therapy for Epilepsy: Mechanisms of Action and Therapeutic Approaches.
Review in Brain sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Peripheral blood inflammatory biomarkers and response to vagus nerve stimulation in pediatric drug-resistant epilepsy: A retrospective cohort study.European journal of pediatrics · 2026Article
- Review
- Acute effects of "Munz Floor"® fascial stretching on autonomic nervous responses assessed by heart rate variability.Frontiers in physiology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vagus Nerve Stimulation (VNS) therapy is a neuromodulation technique useful for the treatment of drug-resistant epilepsy and treatment-resistant depression. This article begins by reviewing the neuroanatomy and physiology of the vagus nerve. It then delves into recent advances in our understanding of VNS's mechanism of action at different levels: how it affects different nerve fibers, how it affects neural pathways, and how it creates anti-inflammatory effects. This article then surveys research to adapt and optimize VNS, guided by an improved understanding of its mechanism of action and descriptions of its effects.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.