ArticleBiology2025
Less Severe Inflammation in Cyclic GMP-AMP Synthase (cGAS)-Deficient Mice with Rabies, Impact of Mitochondrial Injury, and Gut-Brain Axis.
Pannatat Areekul, Thansita Bhunyakarnjanarat, Sakolwan Suebnuson, Kollawat Somsri, Somchanok Trakultritrung, Kris Taveethavornsawat, Tewin Tencomnao, Siwaporn Boonyasuppayakorn, Asada Leelahavanichkul
Abstract read
In one paragraphArticle in Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
9 authors.
Pannatat AreekulDepartment of Research and Development, Queen Saovabha Memorial Institute, Thai Red Cross Society, Bangkok 10330, Thailand.
Thansita BhunyakarnjanaratCenter of Excellence in Translational Research in Inflammation and Immunology (CETRII), Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.
Sakolwan SuebnusonDepartment of Research and Development, Queen Saovabha Memorial Institute, Thai Red Cross Society, Bangkok 10330, Thailand.
Kollawat SomsriCenter of Excellence in Translational Research in Inflammation and Immunology (CETRII), Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.ORCID 0009-0002-4504-9564 Somchanok TrakultritrungDepartment of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.
Kris TaveethavornsawatDepartment of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.
Tewin TencomnaoCenter of Excellence on Natural Products for Neuroprotection and Anti-Ageing (Neur-Age Natura), Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok 10330, Thailand.ORCID 0000-0003-4177-2165 Siwaporn BoonyasuppayakornDepartment of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.ORCID 0000-0002-3631-3573 Asada LeelahavanichkulCenter of Excellence in Translational Research in Inflammation and Immunology (CETRII), Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.ORCID 0000-0002-5566-6403 Funding
Ratchadapiseksompotch Fund, Faculty of Medicine, Chulalongkorn University RA-MF 14/67Ratchadapiseksompotch Fund, Faculty of Medicine, Chulalongkorn University RA-MF 15/66Ratchadapiseksompotch Fund, Faculty of Medicine, Chulalongkorn University RA-MF-18/65The National Research Council of Thailand (NRCT) N32A680647The National Research Council of Thailand (NRCT) N42A680063The National Research Council of Thailand (NRCT) N84A680764
6 · The paper itselfAbstract
Activation of cGAS, a receptor recognizing cytosolic DNA, in macrophages might be associated with rabies (an RNA virus) through mitochondrial damage. A similar mortality rate was observed between cGAS-deficient (cGAS-/-) and wild-type (WT) mice post-CVS-11 strain injection. However, 2 out of 12 cGAS-/- mice (but not WT) survived for 15 days post-injection. At 7 days post-infection, less severe brain inflammation in cGAS-/- mice was demonstrated by the viral abundance in the hippocampus, the expression of proinflammatory genes (
Indexed as
cGASmacrophagesmicrobiotamitochondriarabies
Identifiers
PMID41300373
PMCPMC12650443
What Socratic holds
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LicenceCC BY
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