ArticleBiology2025
Multi-Omics Analysis Reveals Biaxial Regulatory Mechanisms of Cardiac Adaptation by Specialized Racing Training in Yili Horses.
Article in Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Article
- Mitochondrial Adaptations to Exercise Training in Equine Skeletal Muscle: A Narrative Review.Life (Basel, Switzerland) · 2026Review
- Article
- The Effect of Training on the Expression of Protein and Metabolites in the Plasma Exosomes of theAnimals : an open access journal from MDPI · 2026Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors.
Funding
Abstract
Yili horses undergo coordinated physiological adaptations across systems in response to customized training. This study aimed to clarify the molecular mechanisms of these adaptations by integrating analyses of cardiac function and multi-omics (lipidomics, transcriptomics, miRNomics). We collected whole blood samples from ten Yili horses before and after 12 weeks of specialized racing training to perform these analyses. Results showed training induced adaptive cardiac remodeling, with substantial increases in LVIDd and LVIDs. At the molecular level, this was accompanied by extensive blood lipid reprogramming (383 differential lipids), enriched in energy pathways like fatty acid metabolism. Transcriptomic analysis identified 851 differential genes, also enriched in energy-related pathways (e.g., oxidative phosphorylation). We constructed a miRNA-mRNA network (189 pairs), finding miRNAs such as miR-150 and miR-199b regulate key energy-supply mRNAs. Integrated analyses revealed precise modulation of pathways: (1) eca-miR-150 is associated with
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.