Evidence map›Paper›PMID 41300485›Full record

ArticleAntioxidants (Basel, Switzerland)2025

Vitamin K3 Analog Phthiocol Protects Against High Phosphate-Induced Vascular Calcification in Chronic Kidney Disease.

Tsung-Jui Wu, Yi-Cheng Wang, Chia-Wen Lu, Chung-Jen Lee, Bang-Gee Hsu

Abstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tsung-Jui WuInstitute of Medical Science, Tzu Chi University, Hualien 970374, Taiwan.ORCID 0000-0002-3088-659X
Yi-Cheng WangDivision of Nephrology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 970473, Taiwan.
Chia-Wen LuInstitute of Medical Science, Tzu Chi University, Hualien 970374, Taiwan.ORCID 0000-0002-8909-7966
Chung-Jen LeeDepartment of Nursing, Tzu Chi University, Hualien 970374, Taiwan.
Bang-Gee HsuInstitute of Medical Science, Tzu Chi University, Hualien 970374, Taiwan.ORCID 0000-0001-9364-4558

Funding

Buddhist Tzu Chi Medical Foundation, Taiwan TCMF-EP 110-03National Science and Technology Council, R.O.C. MOST 111-2314-B-303-015-MY3
6 · The paper itself

Abstract

Vascular calcification (VC) is a multifactorial pathological deposition of calcium in the vasculature and is associated with severe cardiovascular outcomes, particularly in patients with chronic kidney disease (CKD). Various vitamin K analogs have been found to influence the development of VC. We utilized a high-phosphate-induced VC model in mouse vascular smooth muscle cells (VSMCs) and developed an in vivo VC model using ApoE

Indexed as

chronic kidney diseasehigh-phosphorus dietNrf2/HO-1 antioxidationphthiocolPI3K/Akt pathwayvascular calcification

Identifiers

PMID41300485
PMCPMC12649243

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.