Interplay Between VCAM-1 and PGE2 Levels and Autism Spectrum Disorder Severity in Children-A Preliminary Single-Center Analysis.

Irakli Natroshvili, Tatia Gakharia, Sophia Bakhtadze, Tamar Natsvlishvili, Nana Khachapuridze

Abstract read

In one paragraph

Article in Children (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Irakli NatroshviliGivi Zhvania Pediatric University Clinic, Tbilisi State Medical University, 33 Vazha-Pshavela Avenue, 0186 Tbilisi, Georgia.

Tatia GakhariaGivi Zhvania Pediatric University Clinic, Tbilisi State Medical University, 33 Vazha-Pshavela Avenue, 0186 Tbilisi, Georgia.ORCID 0000-0002-3709-4069

Sophia BakhtadzeGivi Zhvania Pediatric University Clinic, Tbilisi State Medical University, 33 Vazha-Pshavela Avenue, 0186 Tbilisi, Georgia.

Tamar NatsvlishviliGivi Zhvania Pediatric University Clinic, Tbilisi State Medical University, 33 Vazha-Pshavela Avenue, 0186 Tbilisi, Georgia.

Nana KhachapuridzeGivi Zhvania Pediatric University Clinic, Tbilisi State Medical University, 33 Vazha-Pshavela Avenue, 0186 Tbilisi, Georgia.

Funding

Shota Rustaveli National Science Foundation FR-23-22543

6 · The paper itself

Abstract

backgroundThe clinical heterogeneity of autism spectrum disorders (ASDs) results from dynamic interactions between genetic susceptibility and environmental exposures. Autism is increasingly recognized as involving neuroimmune dysregulation, which may contribute to ASD severity. Several studies indicate that ASD patients exhibit increased levels of VCAM-1, suggesting endothelial dysfunction and enhanced leukocyte infiltration into the brain, which may have adverse bearing on synaptic plasticity, axon growth, and repulsion. Similarly, elevated PGE2 drives microglial activation and excitotoxicity. The present study examines possible links between VCAM-1 and PGE2 levels and ASD severity.

methodsVCAM-1 and PGE

resultsVCAM-1 levels were subnormal in 39.3% (

conclusionsInflammation-related biomarkers could be reflecting a heterogeneous set of neuroimmune mechanisms underlying ASD, which may drive behavioral outcomes.

Indexed as

autism severityautism spectrum disorderbiomarkerscytokines

Identifiers

PMID41300606

DOI10.3390/children12111488

PMCPMC12651215

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LicenceCC BY

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