Evidence map›Paper›PMID 41301145›Full record

ArticleBioengineering (Basel, Switzerland)2025

Advancements in High-Resolution Computed Tomography: Revolutionising Bone Health Micro-Research.

Richard Lindtner, Lukas Kampik, David Putzer, Miranda Klosterhuber, Anton Kasper Pallua, Werner Streif, Michael Schirmer, Gerald Degenhart, Rohit Arora, Johannes Dominikus Pallua

Abstract read
In one paragraph

Article in Bioengineering (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Richard LindtnerDepartment of Orthopaedics and Traumatology, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria.
Lukas KampikDepartment of Orthopaedics and Traumatology, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria.
David PutzerDepartment of Orthopaedics and Traumatology, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria.ORCID 0000-0001-9439-0051
Miranda KlosterhuberDepartment of Orthopaedics and Traumatology, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria.
Anton Kasper PalluaFormer Institute for Computed Tomography-Neuro CT, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria.
Werner StreifDepartment of Pediatrics I, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria.
Michael SchirmerOffice Dr. Schirmer, 6060 Hall, Austria.ORCID 0000-0001-9208-7809
Gerald DegenhartCore Facility MicroCT, University Clinic for Radiology, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria.ORCID 0000-0002-9961-1084
Rohit AroraDepartment of Orthopaedics and Traumatology, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria.
Johannes Dominikus PalluaDepartment of Orthopaedics and Traumatology, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria.ORCID 0000-0003-0203-213X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bone disorders such as osteoporosis, osteopenia, and osteoarthritis affect millions worldwide, creating an urgent need for earlier and more accurate assessment of bone health. High-resolution imaging has transformed this field: micro-computed tomography remains the research gold standard for ex vivo and preclinical studies, while high-resolution peripheral quantitative computed tomography enables in vivo clinical assessment of trabecular and cortical bone microarchitecture. Combined with finite element analysis and machine learning, these modalities enable biomechanical modelling, predictive risk stratification, and progress toward personalised treatment. Remaining challenges include cost, limited availability, motion artefacts, and lack of standardisation. This review summarises current advances in imaging and computational methods, highlights their respective strengths and limitations, and outlines future directions required to translate these technologies into routine clinical practice.

Indexed as

bone healthfinite element analysishigh-resolution peripheral quantitative computed tomographymachine learningmicro-computed tomography

Identifiers

PMID41301145
PMCPMC12649248

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.