ReviewBioengineering (Basel, Switzerland)2025
Applications of Fibronectin in Biomedicine and Cosmetics: A Review.
Review in Bioengineering (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Fibronectin (FN) is a key mechanoresponsive glycoprotein within the extracellular matrix (ECM) that contributes to the assembly of a dynamic fibrillar network that is important for maintaining tissue structure and mediating cellular signaling. In this review, we delineate the molecular mechanisms underlying FN's role in barrier restoration, ECM remodeling, and stem cell niche regulation, functions that inform its applications in both regenerative medicine and cosmetic science. In biomedical contexts, FN is recognized as a valuable biomarker for numerous diseases, a promising therapeutic target, and a functional component of biomedical material matrices. FN is involved throughout the skin repair process, making it a physiologically active ingredient for cosmetic anti-aging treatments, alleviating sensitive skin conditions, and enhancing cutaneous immunity. This review also addresses significant translational challenges associated with FN research, including recombinant protein production and rational peptide design, and suggests avenues for future work. Ultimately, studies on FN highlight the complexity of ECM biology and lay the groundwork for innovative approaches to advancing human health and developing new cosmetic treatments.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.