Immunomodulation and Mechanical Characterization of Manuka Honey-Incorporated Near-Field Electrospun Bioresorbable Vascular Grafts.

Alexandra E Snyder, Evan N Main, Gary L Bowlin

Abstract read

In one paragraph

Article in Bioengineering (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Manuka honey and its component, methyl syringate, shift neutrophil release profiles from pro-inflammatory while preserving pro-regenerative growth factor releaseFrontiers in immunology · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Alexandra E SnyderDepartment of Biomedical Engineering, University of Memphis, Memphis, TN 38152, USA.ORCID 0009-0000-5739-1637

Evan N MainDepartment of Biomedical Engineering, University of Memphis, Memphis, TN 38152, USA.ORCID 0000-0001-5527-4939

Gary L BowlinDepartment of Biomedical Engineering, University of Memphis, Memphis, TN 38152, USA.ORCID 0000-0003-0917-8203

Funding

NIH HHS 1R15EB033752-23A1

6 · The paper itself

Abstract

(1) Current synthetic small-diameter vascular grafts fail frequently due to anastomotic hyperplasia and thrombosis caused by mechanical mismatch and incomplete reendothelialization. Polydioxanone near-field electrospun (NFES) vascular templates feature programmable pore sizes to facilitate transmural ingrowth of endothelial cells and show promise in reducing mechanical mismatch, but their potential as drug delivery systems remains unexplored. It was hypothesized that Manuka honey incorporation in NFES templates could reduce neutrophil extracellular trap (NET) release but decrease mechanical strength. (2) Templates were fabricated using 90 mg/mL polydioxanone in 1,1,1,3,3,3-hexafluoro-2-propanol (HFP) and Manuka honey concentrations of 0%, 0.1%, 1%, and 10%

Indexed as

Manuka honeynear-field electrospinningneutrophilspolydioxanonevascular graft

Identifiers

PMID41301226

DOI10.3390/bioengineering12111270

PMCPMC12649915

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.