Evidence map›Paper›PMID 41301416›Full record

ArticleBiomolecules2025

Abietic Acid Induces DNA Damage and Cell Apoptosis in Lung Cancer Cells Through Targeting TOP2A.

Zhiyu Zhu, Jie Gu, Zehua Liao, Mengting Chen, Yun Wang, Jingyi Song, Jing Xia, Xinbing Sui, Shuang Lin, Xueni Sun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zhiyu ZhuSchool of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China.
Jie GuSchool of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China.
Zehua LiaoSchool of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China.
Mengting ChenSchool of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China.
Yun WangSchool of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China.
Jingyi SongSchool of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China.
Jing XiaSchool of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China.
Xinbing SuiSchool of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China.
Shuang LinDepartment of Thoracic Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310058, China.
Xueni SunSchool of Pharmacy, Hangzhou Normal University, Hangzhou 311121, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AbietanesApoptosisDNA DamageDNA Topoisomerases, Type IILung NeoplasmsPoly-ADP-Ribose Binding ProteinsA549 CellsAnimalsCell Line, TumorCell ProliferationCell SurvivalHumansMembrane Potential, MitochondrialMiceMice, NudeMolecular Docking SimulationAbietanesabietic acidDNA Topoisomerases, Type IIPoly-ADP-Ribose Binding ProteinsReactive Oxygen SpeciesTOP2A protein, humanabietic acidDNA damagelung cancernatural productsTOP2A

Identifiers

PMID41301416
PMCPMC12650274

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.