Evidence mapPaperPMID 41301494Full record

ArticleBiomolecules2025

Differential Metabolic Dysregulations in Hepatocellular Carcinoma and Cirrhosis: Insights into Lipidomic Signatures.

Cristina-Paula Ursu, Luminița Elena Furcea, Bogdan Procopeț, Răzvan Alexandru Ciocan, Ștefan Ursu, Claudia Diana Gherman, Dan Vălean, Rodica Sorina Pop, Emil Ioan Moiș, Horia Ștefănescu and 3 more

Abstract readComparative Study
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Cristina-Paula Ursu3rd Surgery Department, "Iuliu Hațieganu" University of Medicine and Pharmacy, Croitorilor Street, No. 19-21, 400162 Cluj-Napoca, Romania.ORCID 0000-0002-3949-6002
Luminița Elena Furcea3rd Surgery Department, "Iuliu Hațieganu" University of Medicine and Pharmacy, Croitorilor Street, No. 19-21, 400162 Cluj-Napoca, Romania.
Bogdan Procopeț"Prof. Dr. Octavian Fodor" Regional Institute of Gastroenterology and Hepatology, Croitorilor Street, No. 19-21, 400162 Cluj-Napoca, Romania.
Răzvan Alexandru CiocanDepartment of Surgery-Practical Skills, "Iuliu Hațieganu" University of Medicine and Pharmacy, Marinescu Street No. 23, 400337 Cluj-Napoca, Romania.ORCID 0000-0003-0252-8258
Ștefan Ursu3rd Surgery Department, "Iuliu Hațieganu" University of Medicine and Pharmacy, Croitorilor Street, No. 19-21, 400162 Cluj-Napoca, Romania.ORCID 0000-0003-3154-0491
Claudia Diana GhermanDepartment of Surgery-Practical Skills, "Iuliu Hațieganu" University of Medicine and Pharmacy, Marinescu Street No. 23, 400337 Cluj-Napoca, Romania.ORCID 0000-0002-8275-9621
Dan Vălean3rd Surgery Department, "Iuliu Hațieganu" University of Medicine and Pharmacy, Croitorilor Street, No. 19-21, 400162 Cluj-Napoca, Romania.ORCID 0000-0002-0571-1624
Rodica Sorina PopDepartment of Community Medicine, "Iuliu Hațieganu" University of Medicine and Pharmacy, Avram Iancu Street, No. 31, 400347 Cluj-Napoca, Romania.ORCID 0000-0001-7390-587X
Emil Ioan Moiș3rd Surgery Department, "Iuliu Hațieganu" University of Medicine and Pharmacy, Croitorilor Street, No. 19-21, 400162 Cluj-Napoca, Romania.
Horia Ștefănescu"Prof. Dr. Octavian Fodor" Regional Institute of Gastroenterology and Hepatology, Croitorilor Street, No. 19-21, 400162 Cluj-Napoca, Romania.ORCID 0000-0002-4034-5471
Carmen SocaciuCenter for Applied Biotechnology Biodiatech, SC Proplanta, 400478 Cluj-Napoca, Romania.ORCID 0000-0002-7352-5057
Nadim Al Hajjar3rd Surgery Department, "Iuliu Hațieganu" University of Medicine and Pharmacy, Croitorilor Street, No. 19-21, 400162 Cluj-Napoca, Romania.ORCID 0000-0001-5986-1233
Florin Graur3rd Surgery Department, "Iuliu Hațieganu" University of Medicine and Pharmacy, Croitorilor Street, No. 19-21, 400162 Cluj-Napoca, Romania.ORCID 0000-0002-5887-3408

Funding

University of Medicine and Pharmacy "Iuliu Hațieganu", Cluj-Napoca, România PCD 771/57/11.01.2023
6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC), the most common primary liver malignancy, usually develops in patients with cirrhosis, yet the metabolic mechanisms that distinguish the two conditions remain poorly understood. This study aimed to explore metabolic dysregulations in HCC compared with cirrhosis and to identify potential biomarkers, especially lipids, with diagnostic and prognostic value. We prospectively studied 81 patients-41 with HCC and 40 with cirrhosis-using high-resolution UHPLC-QTOF-ESI

Indexed as

Carcinoma, HepatocellularLipidomicsLiver CirrhosisLiver NeoplasmsAgedBiomarkersFemaleHumansLipid MetabolismLipidsMaleMiddle AgedBiomarkersLipidsbiomarkerscirrhosisglycerophospholipidshepatocellular carcinomalipidomicssphingolipids

Identifiers

PMID41301494
PMCPMC12650657

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.