Evidence map›Paper›PMID 41301530›Full record

ArticleBiomolecules2025

Altered Short Non-Coding RNA Landscape in the Hippocampus of a Mouse Model of CDKL5 Deficiency Disorder.

Bilal El-Mansoury, Adrian Hayes, Samuel Egan, Jordan Higgins, Stephen B Keane, Elena Langa, Erva Ghani, Morten T Venø, Mona Heiland, David C Henshall and 1 more

Abstract read
In one paragraph

Article in Biomolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Bilal El-MansouryDepartment of Physiology & Medical Physics, RCSI University of Medicine & Health Sciences, D02 YN77 Dublin, Ireland.
Adrian HayesSchool of Medicine, Royal College of Surgeon, D02 YN77 Dublin, Ireland.
Samuel EganDepartment of Physiology & Medical Physics, RCSI University of Medicine & Health Sciences, D02 YN77 Dublin, Ireland.ORCID 0009-0008-9212-2529
Jordan HigginsDepartment of Physiology & Medical Physics, RCSI University of Medicine & Health Sciences, D02 YN77 Dublin, Ireland.ORCID 0009-0006-7786-5557
Stephen B KeaneDepartment of Physiology & Medical Physics, RCSI University of Medicine & Health Sciences, D02 YN77 Dublin, Ireland.
Elena LangaDepartment of Physiology & Medical Physics, RCSI University of Medicine & Health Sciences, D02 YN77 Dublin, Ireland.
Erva GhaniDepartment of Physiology & Medical Physics, RCSI University of Medicine & Health Sciences, D02 YN77 Dublin, Ireland.
Morten T VenøInterdisciplinary Nanoscience Centre, Aarhus University, 8000 Aarhus, Denmark.
Mona HeilandDepartment of Physiology & Medical Physics, RCSI University of Medicine & Health Sciences, D02 YN77 Dublin, Ireland.
David C HenshallDepartment of Physiology & Medical Physics, RCSI University of Medicine & Health Sciences, D02 YN77 Dublin, Ireland.
Omar MamadDepartment of Physiology & Medical Physics, RCSI University of Medicine & Health Sciences, D02 YN77 Dublin, Ireland.

Funding

Taighde Éireann - Research Ireland 22/PATH-S/10668 and 16/RC/3948 and 21/RC/10294_P2
6 · The paper itself

Abstract

CDKL5 deficiency disorder (CDD) is a rare developmental epileptic encephalopathy (DEE) caused by mutations in cyclin-dependent kinase-like 5 (

Indexed as

Epileptic SyndromesHippocampusProtein Serine-Threonine KinasesRNA, Small UntranslatedSpasms, InfantileAnimalsDisease Models, AnimalMaleMiceMicroRNAsCDKL5 protein, mouseMicroRNAsProtein Serine-Threonine KinasesRNA, Small UntranslatedCDKL5 deficiency disorderhippocampusmicroRNAsshort non-coding RNAstRNAs

Identifiers

PMID41301530
PMCPMC12650334

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.