ReviewAntibiotics (Basel, Switzerland)2025
Harnessing Copper Nanoparticles for Antimicrobial Applications: Advances and Challenges.
Review in Antibiotics (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Antimicrobial Strategies in the Era of Resistance: It Is Too Early to Give Up Antibiotic Therapy.International journal of molecular sciences · 2026Review
- Biochemical Modulation of FeChemistry & biodiversity · 2026Article
- Targeting Ferroptosis and Cuproptosis for Antimicrobial Control in Postharvest Preservation.Comprehensive reviews in food science and food safety · 2026Review
- Copper-Doped Silicate Porous Architectures for Hard Tissue Engineering.Journal of functional biomaterials · 2026Article
- Targeting reactivated toxoplasmosis: therapeutic efficacy of the green-synthesized copper nanoparticles combined with pyrimethamine.Antimicrobial agents and chemotherapy · 2026Article
- Copper Complexes: Emerging Micro- and Nanosystems for Dermatological Treatment.Pharmaceutics · 2026Review
- Polyherbal-Mediated Synthesis of Copper Nanoparticles UsingJournal of functional biomaterials · 2026Article
- Cutting-Edge Smart Hydrogel Platforms for Improved Wound Healing.Pharmaceutics · 2026Review
- Enzyme therapy as a promising strategy to overcome multi-drug resistance in pathogens: current advances, key challenges, and future directions.RSC advances · 2026Review
- Advances in functional nanomaterials and piezoelectric biomaterials for personalized intramedullary fixation: addressing age-related orthopedic challenges.Frontiers in chemistry · 2026Review
- Copper nanomaterial antimicrobial coatings: ion release, transparency, and wash durability across biomedical, textile, and packaging applications.Frontiers in chemistry · 2026Review
- Nano-enabled disruption of bacterial virulence and communication in plant pathosystems: emerging strategies for sustainable disease management.Frontiers in plant science · 2026Review
- Coordination-based nanocomposite hydrogel promotes tissue regeneration under infection-compromised conditions.Regenerative biomaterials · 2026Article
- Nanostructured implants for enhanced integration and localized therapy.BioImpacts : BI · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
Abstract
Antimicrobial resistance (AMR) is one of the most significant global health threats of the 21st century, driving the urgent search for alternatives to conventional antibiotics. Copper nanoparticles (CuNPs) have gained attention due to their broad antimicrobial spectrum, cost-effectiveness, and versatile applications in medicine, agriculture, and the food industry. This review provides a systematic overview of the advances in CuNP synthesis, mechanisms of antimicrobial action, biomedical and industrial applications, and associated toxicity issues. A comprehensive literature review was conducted, covering chemical, physical, and biological synthesis strategies; mechanistic studies on microbial inhibition; and experimental reports on biomedical and environmental applications. A comparative analysis revealed opportunities, limitations, and knowledge gaps, with particular emphasis on cytotoxic and ecotoxicological aspects. CuNPs show strong antimicrobial activity against bacteria, fungi, viruses, and multidrug-resistant strains through mechanisms such as reactive oxygen species (ROS) generation, membrane disruption, and DNA/protein interactions. Their use in medical devices, wound dressings, textiles, and packaging materials underlines their application potential. However, cytotoxicity to mammalian cells, ecological risks, and the lack of standardized safety protocols remain critical challenges. Particle size, morphology, and surface chemistry strongly influence both efficacy and toxicity, underlining the importance of controlled synthesis and functionalization. Overall, CuNPs represent a promising strategy to tackle the AMR crisis. Future research should focus on environmentally friendly and surface-modified synthesis approaches, standardized toxicity assessments, and robust regulatory frameworks. By balancing antimicrobial efficacy with biosafety and sustainability, CuNPs could become a transformative platform for clinical, industrial, and environmental applications.
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Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.