Evidence map›Paper›PMID 41302391›Full record

ReviewMolecules (Basel, Switzerland)2025

Aptamer-Based Biosensors for Rapid Detection and Early Warning of Food Contaminants: From Selection to Field Applications.

Cong Wang, Mengyu Ye, Ximeng Zhang, Xin Chai, Huijuan Yu, Boshi Liu, Chengyu Zhang, Yuefei Wang

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Cong WangState Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.ORCID 0009-0006-8197-0405
Mengyu YeState Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Ximeng ZhangState Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Xin ChaiState Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Huijuan YuState Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.ORCID 0000-0003-3222-7608
Boshi LiuCollege of Pharmaceutical Engineering of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Chengyu ZhangState Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Yuefei WangState Key Laboratory of Component-Based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.

Funding

National Natural Science Foundation of China Grant No. 82204769the Eyas Research Project of Tianjin University of Traditional Chinese Medicine No. XJS2022211the National Key Research and Development Program of China No. 2019YFA0905300the Science and Technology Project of Haihe Laboratory of Modern Chinese Medicine No. 22HHZYSS00010the State Key Laboratory of Component-based Chinese Medicine No. CBQM2022109the Tianjin Education Commission Research Program Project No. 2023KJ146
6 · The paper itself

Abstract

Aptamer-based biosensors have emerged as an important and promising technology for applications in food safety, environmental monitoring, and pharmaceutical analysis. Obtained via Systematic evolution of ligands by exponential enrichment (SELEX) screening, these recognition elements exhibit antibody-comparable affinity and specificity, alongside superior chemical stability, easy synthesis, and broad target adaptability. Substantial advances in the field have been marked by the systematic development of food contaminant-specific aptamers, elucidation of their binding mechanisms, and construction of versatile biosensing platforms. The integration of these aptamers with conventional electrochemical and optical sensors has substantially enhanced detection sensitivity and lowered detection limits, particularly for trace-level analytes in complex food matrices. Furthermore, the integration of aptamer technology with novel nanomaterials has facilitated the development of high-performance detection platforms for a wide range of food contaminants, including heavy metals, antibiotics, foodborne pathogens, mycotoxins, pesticides, and food additives. This review systematically summarizes recent advances in SELEX techniques for aptamer screening, highlights the application of aptamer-based biosensors in detecting these contaminants, and discusses current challenges and future prospects in the field of food safety, which establishes a comprehensive framework to advance aptamer-based biosensing technologies for rapid detection and early warning in food safety monitoring.

Indexed as

Aptamers, NucleotideBiosensing TechniquesFood ContaminationSELEX Aptamer TechniqueFood AnalysisFood SafetyHumansAptamers, Nucleotideaptamerearly warningfood contaminationsrapid detectionsafety monitoringSELEX screening

Identifiers

PMID41302391
PMCPMC12655300

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.