Effect of Geometric Design on the Mechanical Performance of Digital Light Processing (DLP)-Printed Microneedles.

This study describes the processing of microneedle (MN) arrays with three different heights of arrowhead (600 µm (A1), 800 µm (A2), and 1000 µm (A3)), pyramid (600 µm (P1), 800 µm (P2), and 1000 µm (P3)), and turret (600 µm (T1), 800 µm (T2), and 1000 µm (T3)) designs using a digital light processing (DLP)-based 3D printing method. The 3D-printed MNs were examined for their morphological characteristics and mechanical performance. Scanning electron microscopy (SEM) imaging confirmed that all of the MNs were fabricated without fracture or bending. Each design exhibited distinct structural characteristics: arrowhead MNs displayed a well-defined morphology with sharp tips, pyramid MNs showed slight layering, and turret MNs, characterized by a wider base and sharp tips, had a smoother surface compared to the other designs. Mechanical tests revealed that the arrowhead MNs carried less load and were more prone to bending, while the pyramid and turret designs provided higher mechanical stability and penetration capacity. The pyramid design (P3) showed the highest mechanical strength, while turret MNs offered a more stable performance despite lower penetration capacity. These findings highlight the critical role of geometric design in optimizing MN performance for effective transdermal drug delivery.