ArticleMicromachines2025
Discrimination Between Normal Skin Fibroblasts and Malignant Melanocytes Using Dielectrophoretic and Flow-Induced Shear Forces.
Article in Micromachines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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3 authors.
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Abstract
Cell analysis is vital in clinical diagnostics and cell engineering research. Among the various analytical techniques, dielectrophoresis (DEP) is a particularly promising label-free method for distinguishing biological particles, which eliminates the need for fluorescent dyes or magnetic beads. In this study, we present a high-precision single-cell analysis system based on the evaluation of DEP forces in a controlled microfluidic flow environment. The system integrates a microfluidic chamber equipped with an electrode array to exert DEP forces and flow-induced shear forces to facilitate force balance analysis. We quantitatively characterized the DEP response to successfully discriminate between healthy skin cells and cancer cells using the proposed DEP-based cell-sorting platform. The proposed system successfully distinguished between these cell types even when their dielectrophoretic properties were similar, highlighting its potential for sensitive and selective cell classification in biomedical applications.
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Registered trials
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