Evidence map›Paper›PMID 41303309›Full record

ArticleInternational journal of molecular sciences2025

Myokine Levels in Relation to Bone Markers and Adipokines in Children with Prader-Willi Syndrome During Growth Hormone Therapy and Dietary Intervention.

Joanna Gajewska, Magdalena Chełchowska, Katarzyna Szamotulska, Małgorzata Strucińska, Witold Klemarczyk, Jadwiga Ambroszkiewicz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Joanna GajewskaDepartment of Screening Tests and Metabolic Diagnostics, Institute of Mother and Child, 01-211 Warsaw, Poland.ORCID 0000-0002-1349-0155
Magdalena ChełchowskaDepartment of Screening Tests and Metabolic Diagnostics, Institute of Mother and Child, 01-211 Warsaw, Poland.ORCID 0000-0002-6174-6813
Katarzyna SzamotulskaDepartment of Epidemiology and Biostatistics, Institute of Mother and Child, 01-211 Warsaw, Poland.
Małgorzata StrucińskaDepartment of Nutrition, Institute of Mother and Child, 01-211 Warsaw, Poland.ORCID 0000-0001-5538-0459
Witold KlemarczykDepartment of Nutrition, Institute of Mother and Child, 01-211 Warsaw, Poland.ORCID 0000-0002-7088-0117
Jadwiga AmbroszkiewiczDepartment of Screening Tests and Metabolic Diagnostics, Institute of Mother and Child, 01-211 Warsaw, Poland.ORCID 0000-0001-7320-7561

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Data on the interplay between muscle, bone, and adipose tissue metabolism in normal-weight children with Prader-Willi syndrome (PWS) undergoing growth hormone (GH) therapy and dietary interventions are limited. This study aimed to assess the myokine profile and explore the associations between myokines, bone markers, adipokines, and body composition in these patients. The study included 26 children with PWS and 26 age-matched healthy controls. Serum levels of irisin, myostatin (MSTN), fibroblast growth factor-2, insulin-like growth factor-I (IGF-I), IGF-binding protein-2, bone alkaline phosphatase (BALP), osteocalcin (OC), carboxylated OC (Gla-OC), periostin, soluble receptor activator of nuclear factor kappa-B ligand, tartrate-resistant acid phosphatase 5b, leptin/soluble leptin receptor, adiponectin, and proinsulin were measured using immunoenzymatic assays. Children with PWS had significantly lower lean mass (

Indexed as

AdipokinesBone and BonesHuman Growth HormonePrader-Willi SyndromeAdolescentBiomarkersBody CompositionCase-Control StudiesChildChild, PreschoolFemaleHumansMaleMyokinesMyostatinOsteocalcinAdipokinesBiomarkersHuman Growth HormoneMyokinesMyostatinOsteocalcinbody compositionIGF-binding protein-2insulin-like growth factor-IirisinmyostatinosteocalcinPrader–Willi syndrome

Identifiers

PMID41303309
PMCPMC12652224

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.