Evidence map›Paper›PMID 41303339›Full record

ArticleInternational journal of molecular sciences2025

Loss of Dioxin Response Element-Mediated Induction of PKM2 Reprograms Hepatic Metabolism in Response to TCDD.

Karina Orlowska, Rance Nault, Tim Zacharewski

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Karina OrlowskaDepartment of Biochemistry & Molecular Biology, Michigan State University, East Lansing, MI 48824, USA.
Rance NaultInstitute for Integrative Toxicology, Michigan State University, East Lansing, MI 48824, USA.ORCID 0000-0002-6822-4962
Tim ZacharewskiDepartment of Biochemistry & Molecular Biology, Michigan State University, East Lansing, MI 48824, USA.ORCID 0000-0002-3662-7919

Funding

VOLATILE ORGANIC CONTAMINANTS--QUANTIFYING THEIR MOVEMENT IN THE UNSATURATED ZONEP42ES004911 · NIEHS · MICHIGAN STATE UNIVERSITY · PI Brian P. Johnson · 1989 to 2026
$64.9M
AhR-dependent Pkm2 regulation in NAFLD progressionR01ES029541 · NIEHS · MICHIGAN STATE UNIVERSITY · PI ZACHAREWSKI, TIMOTHY R. · 2019 to 2023
$1.9M
NIEHS NIH HHS P42 ES004911NIEHS NIH HHS R01 ES029541NIEHS NIH HHS R01ES029541
6 · The paper itself

Abstract

2,3,7,8-Tetrachlorodibenzo-

Indexed as

LiverPolychlorinated DibenzodioxinsPyruvate KinaseResponse ElementsAnimalsGene Expression RegulationHepatocytesMaleMiceMice, Inbred C57BLReceptors, Aryl HydrocarbonThyroid HormonesPkm protein, mousePolychlorinated DibenzodioxinsPyruvate KinaseReceptors, Aryl HydrocarbonThyroid HormonesliverPKM2TCDD

Identifiers

PMID41303339
PMCPMC12652037

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.