Evidence map›Paper›PMID 41303369›Full record

ReviewInternational journal of molecular sciences2025

Genomic Signatures of MASLD: How Genomics Is Redefining Our Understanding of Metabolic Liver Disease.

Peter Saliba-Gustafsson, Jennifer Härdfeldt, Matteo Pedrelli, Paolo Parini

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Linked Intronic Polymorphisms of theInternational journal of molecular sciences · 2026
    Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Peter Saliba-GustafssonCardio Metabolic Unit, Department of Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden.ORCID 0000-0002-7807-9009
Jennifer HärdfeldtCardio Metabolic Unit, Department of Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden.ORCID 0000-0002-6190-7365
Matteo PedrelliCardio Metabolic Unit, Department of Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden.ORCID 0000-0003-0771-0569
Paolo PariniCardio Metabolic Unit, Department of Medicine, Karolinska Institutet, 171 77 Stockholm, Sweden.ORCID 0000-0002-6541-8542

Funding

Åke Wibergs Stiftelse M24-0065European Atherosclerosis Society N/AEuropean Union 101057619European Union 101136305Karolinska Institutet 2024-02617Karolinska Institutet 2-776/2024Stockholm County Council FoUI-975446Swedish Heart-Lung Foundation 20200736Swedish Heart-Lung Foundation 20230737Swedish Research Council 521-2013-2804
6 · The paper itself

Abstract

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver condition globally, driven by strong genetic and environmental components. This review summarizes recent advances in understanding the genetic architecture of MASLD. Genome-wide association studies (GWAS) have identified several key risk variants, primarily in genes such as

Indexed as

Non-alcoholic Fatty Liver DiseaseAcyltransferasesAdaptor Proteins, Signal TransducingGenome-Wide Association StudyHumansLipid MetabolismMembrane ProteinsPhospholipases A2, Calcium-IndependentPrevalenceRisk FactorsAcyltransferasesAdaptor Proteins, Signal TransducingGCKR protein, humanMBOAT7 protein, humanMembrane ProteinsPhospholipases A2, Calcium-IndependentPNPLA3 protein, humanTM6SF2 protein, humanfatty liver diseasefunctional genomicsgeneticsgenome-wide association studyGWASMASLDnetwork medicineperturb-seq

Identifiers

PMID41303369
PMCPMC12652521

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.