Evidence map›Paper›PMID 41303383›Full record

ArticleInternational journal of molecular sciences2025

Defensin-Rich Platelets Drive Pro-Tumorigenic Programs in Pancreatic Adenocarcinoma.

Jonathan Gonzalez-Ruiz, Miryam Sarmiento-Casas, Ivan Bahena-Ocampo, Magali Espinosa, Gisela Ceballos-Cancino, Karla Vazquez-Santillan, Vilma Maldonado, Jorge Melendez-Zajgla

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jonathan Gonzalez-RuizDepartment of Ciencias de la Salud, Universidad Autónoma Metropolitana-Iztapalapa, Mexico City 09310, Mexico.ORCID 0000-0003-4323-4061
Miryam Sarmiento-CasasLaboratorio de Genómica Funcional del Cáncer, Instituto Nacional de Medicina Genómica, Mexico City 14610, Mexico.ORCID 0009-0003-2800-5540
Ivan Bahena-OcampoDepartment of Ciencias de la Salud, Universidad Autónoma Metropolitana-Iztapalapa, Mexico City 09310, Mexico.ORCID 0000-0002-1361-3573
Magali EspinosaLaboratorio de Genómica Funcional del Cáncer, Instituto Nacional de Medicina Genómica, Mexico City 14610, Mexico.ORCID 0000-0003-4657-6382
Gisela Ceballos-CancinoLaboratorio de Genómica Funcional del Cáncer, Instituto Nacional de Medicina Genómica, Mexico City 14610, Mexico.ORCID 0000-0003-4880-7084
Karla Vazquez-SantillanLaboratorio de Genómica Funcional del Cáncer, Instituto Nacional de Medicina Genómica, Mexico City 14610, Mexico.ORCID 0000-0003-1380-2494
Vilma MaldonadoLaboratorio de Epigenética, Instituto Nacional de Medicina Genómica, Mexico City 14610, Mexico.ORCID 0000-0002-7254-5961
Jorge Melendez-ZajglaLaboratorio de Genómica Funcional del Cáncer, Instituto Nacional de Medicina Genómica, Mexico City 14610, Mexico.ORCID 0000-0002-2209-1607

Funding

Secretaría de Ciencia, Humanidades, Tecnología e Innovación CBF-2025-I-4446
6 · The paper itself

Abstract

Pancreatic Ductal Adenocarcinoma (PDAC) is one of the most aggressive and lethal malignancies, driven by late diagnosis, limited therapeutic options, and high metastatic potential. Beyond their canonical roles in hemostasis, platelets have emerged as active modulators of tumor progression and promising noninvasive biomarkers. Among platelet-associated molecules, α-defensins, particularly Defensin Alpha 1/3 (

Indexed as

alpha-DefensinsBlood PlateletsCarcinoma, Pancreatic DuctalPancreatic NeoplasmsAnimalsCell Line, TumorCell MovementCell ProliferationEpithelial-Mesenchymal TransitionGene Expression Regulation, NeoplasticHumansZebrafishalpha-Defensinsalpha-defensinsDEFA1/3pancreatic cancerparticles like-plateletsplateletstranscriptomicstumor progressionzebrafish xenograft

Identifiers

PMID41303383
PMCPMC12652293

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.