Evidence map›Paper›PMID 41303426›Full record

ArticleInternational journal of molecular sciences2025

Molecular Diagnostics Supporting a ≥35% Diffuse Peritubular Capillaritis Extent Threshold for Diagnosis of AMR-A Retrospective Dual Center Study.

Michael Eder, Marian C Clahsen-van Groningen, Michael Mengel, Haris Omic, Daniel Cejka, Benjamin Adam, Nicolas Kozakowski, Željko Kikić

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Michael EderDivision of Nephrology and Dialysis, Department of Internal Medicine III, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria.ORCID 0000-0002-6341-1275
Marian C Clahsen-van GroningenUniversity Hospital RWTH Aachen, Department of Nephrology, 52074 Aachen, Germany.
Michael MengelDepartment of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB T6G 2R3, Canada.ORCID 0000-0002-7222-3356
Haris OmicDivision of Nephrology and Dialysis, Department of Internal Medicine III, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria.
Daniel CejkaDepartment of Medicine III, Nephrology, Hypertension, Transplantation and Rheumatology, Ordensklinikum Linz-Elisabethinen, 4010 Linz, Austria.ORCID 0000-0001-7162-1443
Benjamin AdamDepartment of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB T6G 2R3, Canada.ORCID 0000-0003-1908-1739
Nicolas KozakowskiDepartment of Pathology, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0001-9180-620X
Željko KikićDivision of Nephrology and Dialysis, Department of Internal Medicine III, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peritubular capillaritis (ptc) is a hallmark lesion of antibody-mediated rejection (AMR), but the grading of its extent is historically based on arbitrary defined cut-offs. Molecular AMR diagnosis via intragraft gene expression measurements may provide evidence to challenge established ptc categories. We retrospectively included 38 renal allograft biopsies from clinical routine, performed because of suspicion of AMR. Biopsies were re-assessed by an experienced nephropathologist and intragraft gene expression was measured using the NanoString nCounter

Indexed as

CapillariesGraft RejectionKidney TransplantationPathology, MolecularAdultBiopsyFemaleHumansMaleMiddle AgedRetrospective Studiesantibody-mediated rejectionintragraft gene expressionkidney transplantationnephrologyperitubular capillaritis

Identifiers

PMID41303426
PMCPMC12652923

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.