Evidence map›Paper›PMID 41303450›Full record

ArticleInternational journal of molecular sciences2025

Effects of Inhibitors of the Activity of the Circulating Renin-Angiotensin System on the Growth and Proliferation of Endometrial Cancer Cells.

Sarah J Delforce, Riazuddin Mohammed, Tess L Symington, Yu Wang, Nicole M Verrills, Eugenie R Lumbers, Kirsty G Pringle

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sarah J DelforceSchool of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, NSW 2308, Australia.
Riazuddin MohammedSchool of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, NSW 2308, Australia.
Tess L SymingtonSchool of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, NSW 2308, Australia.ORCID 0009-0009-0837-2793
Yu WangR&D, Beroni Group Ltd., Sydney, NSW 2000, Australia.
Nicole M VerrillsSchool of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, NSW 2308, Australia.
Eugenie R LumbersSchool of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, NSW 2308, Australia.
Kirsty G PringleSchool of Biomedical Sciences and Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, NSW 2308, Australia.ORCID 0000-0002-6770-0496

Funding

Hunter Medical Research Institute G1300654John Hunter Charitable Trust G1200650
6 · The paper itself

Abstract

Endometrial cancers increase expression of the renin-angiotensin system (RAS). This study aimed to determine if inhibiting the RAS would reduce the viability and proliferation of endometrial cancer cells. The expression of RAS genes was measured in three endometrial epithelial adenocarcinoma cell lines (Ishikawa, HEC-1-A, AN3CA). Ishikawa cells had the highest expression of

Indexed as

Cell ProliferationEndometrial NeoplasmsRenin-Angiotensin SystemAmidesAngiotensin-Converting Enzyme InhibitorsAngiotensin II Type 1 Receptor BlockersCell Line, TumorCell SurvivalFemaleFumaratesGene Expression Regulation, NeoplasticHumansLosartanReceptor, Angiotensin, Type 1ReninRenin InhibitorsaliskirenAmidesAngiotensin-Converting Enzyme InhibitorsAngiotensin II Type 1 Receptor BlockersFumaratesLosartanReceptor, Angiotensin, Type 1ReninRenin InhibitorsTelmisartanACE inhibitorsangiotensin receptor blockersendometrial cancerrenin–angiotensin systemrenin inhibitors

Identifiers

PMID41303450
PMCPMC12652496

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.