ReviewInternational journal of molecular sciences2025
The Role of mRNA Alternative Processing in Mammalian Neurodevelopment.
Review in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Wiedemann-Steiner Syndrome (WSS): A Neonatal Case Report Expanding the Phenotypic Spectrum of a Previously Reported Missense Variant.International journal of molecular sciences · 2026Review
- Nonsense-mediated mRNA decay and associated splicing patterns in neurodevelopmental disorders.Frontiers in molecular biosciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
The mammalian brain undergoes a series of orderly developmental events, including neurogenesis, neuronal migration, axon guidance, and synaptic connection. These neurodevelopmental mechanisms have traditionally been characterized through studies focused on transcriptional control; however, a growing body of evidence highlights the critical roles of co- or post-transcriptional steps like alternative splicing, alternative polyadenylation, and RNA chemical modification in orchestrating brain development. This review discusses the recent progress made toward understanding the influence of alternative mRNA processing on neurodevelopment, including three aspects: the key mRNA processing events that drive neuronal differentiation from stem/progenitor cells; the regulatory mechanisms that govern cell-type and stage-specific mRNA-processing patterns; and the neuropathological consequences of mRNA-processing dysregulation. By integrating these insights, we aim to deepen the understanding of how mRNA alternative processing influences neurodevelopment and its implications for neurological health.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.