Evidence map›Paper›PMID 41303581›Full record

ArticleInternational journal of molecular sciences2025

Protective Role of p66Shc Deletion in Physiological Renal Aging: Effects on G Protein-Coupled Receptor 124 Expression and Associated Cellular Senescence.

Carla Iacobini, Martina Vitale, Federica Sentinelli, Antonietta Lucarelli, Jonida Haxhi, Ilaria Sergio, Giuseppe Pugliese, Stefano Menini

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Carla IacobiniDepartment of Clinical and Molecular Medicine, "La Sapienza" University, 00189 Rome, Italy.ORCID 0000-0002-0737-1213
Martina VitaleDepartment of Clinical and Molecular Medicine, "La Sapienza" University, 00189 Rome, Italy.ORCID 0000-0003-4856-7279
Federica SentinelliDepartment of Clinical Medicine, Public Health, Life and Environmental Sciences (MeSVA), University of L'Aquila, 67100 L'Aquila, Italy.
Antonietta LucarelliDepartment of Clinical and Molecular Medicine, "La Sapienza" University, 00189 Rome, Italy.
Jonida HaxhiDepartment of Clinical and Molecular Medicine, "La Sapienza" University, 00189 Rome, Italy.ORCID 0000-0003-2319-869X
Ilaria SergioTumor Immunology and Immunotherapy Unit, IRCCS Regina Elena National Cancer Institute, 00144 Rome, Italy.
Giuseppe PuglieseDepartment of Clinical and Molecular Medicine, "La Sapienza" University, 00189 Rome, Italy.ORCID 0000-0003-1574-0397
Stefano MeniniDepartment of Clinical and Molecular Medicine, "La Sapienza" University, 00189 Rome, Italy.ORCID 0000-0001-7328-2385

Funding

Sapienza University of Rome Ateneo 2023-2025
6 · The paper itself

Abstract

The adaptor protein p66Shc regulates oxidative stress and aging, but its role in renal aging is unclear. We investigated the effects of p66Shc deletion on age-related kidney changes, focusing on G protein-coupled receptor 124 (GPR124) and cellular senescence. Using kidney and urine samples from p66Shc

Indexed as

AgingCellular SenescenceKidneyReceptors, G-Protein-CoupledShc Signaling Adaptor ProteinsSrc Homology 2 Domain-Containing, Transforming Protein 1AnimalsGene DeletionMaleMiceMice, Inbred C57BLMice, KnockoutOxidative StressPodocytesReceptors, EstrogenGPER1 protein, mouseReceptors, EstrogenReceptors, G-Protein-CoupledShc1 protein, mouseShc Signaling Adaptor ProteinsSrc Homology 2 Domain-Containing, Transforming Protein 1cellular senescencefibrosisglomerulosclerosisGPR124healthspanmitochondrial signalingoxidative stresspodocytes

Identifiers

PMID41303581
PMCPMC12652738

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.